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Conjunctival Melanoma: Association of Cyclooxygenase-2 Tumor Expression to Prognosis

2018-05Journal article Open access
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dc.contributor.authorProença, R
dc.contributor.authorSantos, M
dc.contributor.authorFonseca, C
dc.contributor.authorFernandes, J
dc.contributor.authorGaspar, MF
dc.contributor.authorProença, R
dc.date.accessioned2018-12-19T15:36:12Z
dc.date.available2018-12-19T15:36:12Z
dc.date.issued2018-05
dc.description.abstractPURPOSE: Conjunctival melanoma is a rare but potentially lethal tumor. Its biologic profile is still largely unknown, with recent studies aiming at establishing histopathological and genetic tumor profiles. The aim of this study was to analyze the association between clinicopathological characteristics and tumor expression of cyclooxygenase-2 (COX-2) to prognosis, assessing its usefulness as a possible prognostic marker. METHODS: Case series of 50 patients from 1991 to 2008 with pathologically proven conjunctival melanoma. Demographic, clinical, and pathological characteristics were evaluated by reviewing clinical files and pathology. Expression of COX-2 was studied by immunohistochemistry of formalin-fixed paraffin-embedded tissue samples of 20 melanomas. Samples were classified in a score which included intensity of staining and percentage of cells with positive reactivity. RESULTS: Clinicopathological features significantly associated (p < .05) with a poor prognosis (death) included involvement of fornix and tarsal conjunctiva, tumor thickness exceeding 2 mm, local tumor recurrence, lymph node, and systemic metastasis. In the immunohistochemistry study (n = 20), 18 cases expressed COX-2 although with different scores. However, only cases with a high score were associated with a poor outcome. Multivariate association analysis revealed that recurrence rate, metastasis, corneal invasion, and tumor thickness were associated with high score cases and, therefore, with a clinical profile with a higher risk of death. CONCLUSIONS: Results suggest that higher COX-2 expression may be a negative prognostic factor in conjunctival melanoma. Further studies can address the potential use of anti-COX-2 drugs as adjuvant therapy of this disease.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGraefes Arch Clin Exp Ophthalmol. 2018 May;256(5):989-995.pt_PT
dc.identifier.doi10.1007/s00417-017-3864-xpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/3141
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.subjectAdultpt_PT
dc.subjectAgedpt_PT
dc.subjectAged, 80 and overpt_PT
dc.subjectBiomarkers, Tumor/metabolismpt_PT
dc.subjectConjunctival Neoplasms/enzymologypt_PT
dc.subjectCyclooxygenase 2/metabolismpt_PT
dc.subjectFemalept_PT
dc.subjectHumanspt_PT
dc.subjectImmunohistochemistrypt_PT
dc.subjectLymphatic Metastasispt_PT
dc.subjectMalept_PT
dc.subjectMelanoma/enzymologypt_PT
dc.subjectMiddle Agedpt_PT
dc.subjectPrognosispt_PT
dc.subjectRetrospective Studiespt_PT
dc.subjectYoung Adultpt_PT
dc.subjectCHLC OFTpt_PT
dc.subjectConjunctival Neoplasms/pathology
dc.subjectMelanoma/pathology
dc.titleConjunctival Melanoma: Association of Cyclooxygenase-2 Tumor Expression to Prognosispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage995pt_PT
oaire.citation.issue5pt_PT
oaire.citation.startPage989pt_PT
oaire.citation.titleGraefe's Archive for Clinical and Experimental Ophthalmologypt_PT
oaire.citation.volume256pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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