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A Novel Online Prognostic Tool to Predict Long-Term Survival after Liver Resection for Intrahepatic Cholangiocarcinoma: The "Metro-Ticket" Paradigm

2019-08Journal article Open access
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dc.contributor.authorSahara, K
dc.contributor.authorTsilimigras, D
dc.contributor.authorMehta, R
dc.contributor.authorBagante, F
dc.contributor.authorGuglielmi, A
dc.contributor.authorAldrighetti, L
dc.contributor.authorAlexandrescu, S
dc.contributor.authorPinto Marques, H
dc.contributor.authorShen, F
dc.contributor.authorKoerkamp, B
dc.contributor.authorEndo, I
dc.contributor.authorPawlik, T
dc.date.accessioned2021-04-14T14:01:10Z
dc.date.available2021-04-14T14:01:10Z
dc.date.issued2019-08
dc.description.abstractBackground: The aim of the current study was to develop an online calculator to predict survival after liver resection for intrahepatic cholangiocarcinoma (ICC) based on the "metro-ticket" paradigm. Methods: Between 1990 and 2016, patients who underwent liver resection for ICC were identified in an international multi-institutional database. The final multivariable model of survival was used to develop an online prognostic calculator of survival. Results: Among 643 patients, actual 5-year overall survival (OS) after resection for ICC was 42.7%. On multivariable analysis, CA19-9 > 200 (hazard ratio (HR), 2.62; 95% CI, 2.01-3.42), sum of the number and largest tumor size >7 (HR, 1.88; 95% CI, 1.46-2.42), N1 disease (HR, 2.87; 95% CI, 1.98-4.16), R1 resection (HR, 1.72; 95% CI, 1.21-2.46), poor/undifferentiated tumor grade (HR, 1.74; 95% CI, 1.25-2.44), major vascular invasion (HR, 1.47; 95% CI, 1.03-2.10), and adjuvant chemotherapy (HR, 0.64; 95% CI, 0.45-0.89) were significantly associated with survival and were included in the online calculator. The predictive accuracy of the model was good to very good as the C-statistics to predict 5-year OS was 0.696 in the training dataset and 0.672 with bootstrapping resamples (n = 5000) in the test dataset. Conclusion: A novel, online calculator was developed to estimate the 5-year survival probability for patients undergoing resection for ICC. This tool could help provide useful information to guide treatment decision-making and inform conversations about prognosis.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Surg Oncol. 2019 Aug;120(2):223-230.pt_PT
dc.identifier.doi10.1002/jso.25480pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/3651
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.subjectAgedpt_PT
dc.subjectBile Duct Neoplasmspt_PT
dc.subjectCholangiocarcinomapt_PT
dc.subjectFemalept_PT
dc.subjectHumanspt_PT
dc.subjectMalept_PT
dc.subjectMiddle Agedpt_PT
dc.subjectOnline Systemspt_PT
dc.subjectPredictive Value of Testspt_PT
dc.subjectPrognosispt_PT
dc.subjectSurvival Ratept_PT
dc.subjectBile Ducts, Intrahepaticpt_PT
dc.subjectHepatectomypt_PT
dc.subjectHCC CIRpt_PT
dc.titleA Novel Online Prognostic Tool to Predict Long-Term Survival after Liver Resection for Intrahepatic Cholangiocarcinoma: The "Metro-Ticket" Paradigmpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage230pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage223pt_PT
oaire.citation.titleJournal of Surgical Oncologypt_PT
oaire.citation.volume120pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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