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Obesity and Diabetes Are Associated with Disability in Women with Hand Osteoarthritis. Results from the EpiReumaPt Nationwide Study

2021Journal article Open access
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dc.contributor.authorCruz, M
dc.contributor.authorRodrigues, AM
dc.contributor.authorDias, S
dc.contributor.authorSepriano, A
dc.contributor.authorCanhão, H
dc.contributor.authorGouveia, N
dc.contributor.authorRamiro, S
dc.contributor.authorBranco, JC
dc.date.accessioned2022-01-21T15:29:40Z
dc.date.available2022-01-21T15:29:40Z
dc.date.issued2021
dc.description.abstractBackground: Hand osteoarthritis (HOA) is a highly prevalent rheumatic disease that predominates in females and causes pain and loss of functional capacity. Obesity and metabolic syndrome have been previously suggested to associate with the severity of HOA, but clarity on these associations is yet to be achieved. Objective: Test the association between obesity and other components of the metabolic syndrome and disability in women with hand osteoarthritis (HOA). Design: Individuals from EpiReumaPt epidemiological community-based study (2011-2013) are representative of the Portuguese population. Women with diagnosis of primary HOA were included. Primary outcome: hand functional status, assessed by Cochin questionnaire. Secondary outcomes: hand pain, assessed by visual analogue scale and tender hand joint count (THJ). Explanatory variables: obesity, diabetes mellitus, arterial hypertension and hypercholesterolemia. Possible associations between obesity and the other components of metabolic syndrome with Cochin score, hand pain and THJ were tested in a multivariable linear regression model. Potential confounders considered: age, education level and countrywide distribution. Results: 473 women with primary HOA were included. Forty percent were overweight and 29% obese. Ninety-three (19.8%) participants had diabetes, 261 (55.8%) reported hypertension and 261 (55.9%) hypercholesterolemia. Mean Cochin score was 15.5±14.8, mean pain VAS was 4.7±2.6 and mean THJ 1.4±3. In the multivariable analysis, obesity (β 4.6 CI 0.7;8.5) and diabetes (β 4.0 CI 0.4;7.6) were found to significantly associate with HOA functional disability. In addition, diabetes, but not obesity, associated with hand pain. There was no association between obesity or diabetes with THJ. Conclusion: In a Portuguese female population with primary HOA, obesity and diabetes mellitus independently associated with a worse hand functional status. These data add to evidence suggesting a role of metabolic factors in the severity of HOA.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationActa Reumatol Port. Jul-Sep 2021;46(3):208-217.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/3962
dc.language.isoengpt_PT
dc.publisherSociedade Portuguesa de Reumatologiapt_PT
dc.subjectHCC REUMpt_PT
dc.subjectFemalept_PT
dc.subjectHumanspt_PT
dc.subjectDiabetes Mellitus*pt_PT
dc.subjectHand Joints*pt_PT
dc.subjectObesity / complicationspt_PT
dc.subjectObesity / epidemiologypt_PT
dc.subjectOsteoarthritis* / complicationspt_PT
dc.subjectOsteoarthritis* / epidemiologypt_PT
dc.subjectPain Measurementpt_PT
dc.titleObesity and Diabetes Are Associated with Disability in Women with Hand Osteoarthritis. Results from the EpiReumaPt Nationwide Studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage217pt_PT
oaire.citation.startPage208pt_PT
oaire.citation.titleActa Reumatológica Portuguesapt_PT
oaire.citation.volume46pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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