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Increased 30-Day Mortality in Very Old ICU Patients with COVID-19 Compared to Patients with Respiratory Failure without COVID-19

2022-04Journal article Open access
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dc.contributor.authorGuidet, B
dc.contributor.authorJung, C
dc.contributor.authorFlaatten, H
dc.contributor.authorFjølner, J
dc.contributor.authorArtigas, A
dc.contributor.authorBollen Pinto, B
dc.contributor.authorSchefold, J
dc.contributor.authorBeil, M
dc.contributor.authorSigal, S
dc.contributor.authorVernon van Heerden, P
dc.contributor.authorSzczeklik, W
dc.contributor.authorJoannidis, M
dc.contributor.authorOeyen, S
dc.contributor.authorKondili, E
dc.contributor.authorMarsh, B
dc.contributor.authorAndersen, F
dc.contributor.authorMoreno, R
dc.contributor.authorCecconi, M
dc.contributor.authorLeaver, S
dc.contributor.authorDe Lange, D
dc.contributor.authorBoumendil, A
dc.contributor.authorEller, P
dc.contributor.authorJoannidis, M
dc.contributor.authorMesotten, D
dc.contributor.authorReper, P
dc.contributor.authorOeyen, S
dc.contributor.authorSwinnen, W
dc.contributor.authorBrix, H
dc.contributor.authorBrushoej, J
dc.contributor.authorVillefrance, M
dc.contributor.authorNedergaard, H
dc.contributor.authorBjerregaard, A
dc.contributor.authorBalleby, I
dc.contributor.authorAndersen, K
dc.contributor.authorHansen, M
dc.contributor.authorUhrenholt, S
dc.contributor.authorBundgaard, H
dc.contributor.authorFjølner, J
dc.contributor.authorHussein, A
dc.contributor.authorSalah, R
dc.contributor.authorAli, Y
dc.contributor.authorWassim, K
dc.contributor.authorElgazzar, Y
dc.contributor.authorTharwat, S
dc.contributor.authorAzzam, A
dc.contributor.authorHabib, A
dc.contributor.authorAbosheaishaa, H
dc.contributor.authorAzab, M
dc.contributor.authorLeaver, S
dc.contributor.authorGalbois, A
dc.contributor.authorUrbina, T
dc.contributor.authorCharron, C
dc.contributor.authorGuerot, E
dc.contributor.authorBesch, G
dc.contributor.authorRigaud, JP
dc.contributor.authorMaizel, J
dc.contributor.authorDjibré, M
dc.contributor.authorBurtin, P
dc.contributor.authorGarcon, P
dc.contributor.authorNseir, S
dc.contributor.authorValette, X
dc.contributor.authorAlexandru, N
dc.contributor.authorMarin, N
dc.contributor.authorVaissiere, M
dc.contributor.authorPlantefeve, G
dc.contributor.authorVanderlinden, T
dc.contributor.authorJurcisin, I
dc.contributor.authorMegarbane, B
dc.contributor.authorCaillard, A
dc.contributor.authorValent, A
dc.contributor.authorGarnier, M
dc.contributor.authorBesset, S
dc.contributor.authorOziel, J
dc.contributor.authorRaphalen, J
dc.contributor.authorDauger, S
dc.contributor.authorDumas, G
dc.contributor.authorGoncalves, B
dc.contributor.authorPiton, G
dc.contributor.authorBarth, E
dc.contributor.authorGoebel, U
dc.contributor.authorBarth, E
dc.contributor.authorKunstein, A
dc.contributor.authorSchuster, M
dc.contributor.authorWelte, M
dc.contributor.authorLutz, M
dc.contributor.authorMeybohm, P
dc.contributor.authorSteiner, S
dc.contributor.authorPoerner, T
dc.contributor.authorHaake, H
dc.contributor.authorSchaller, S
dc.contributor.authorSchaller, S
dc.contributor.authorSchaller, S
dc.contributor.authorKindgen-Milles, D
dc.contributor.authorMeyer, C
dc.contributor.authorKurt, M
dc.contributor.authorKuhn, K
dc.contributor.authorRanderath, W
dc.contributor.authorWollborn, J
dc.contributor.authorDindane, Z
dc.contributor.authorKabitz, H
dc.contributor.authorVoigt, I
dc.contributor.authorShala, G
dc.contributor.authorFaltlhauser, A
dc.contributor.authorRovina, N
dc.contributor.authorAidoni, Z
dc.contributor.authorChrisanthopoulou, E
dc.contributor.authorPapadogoulas, A
dc.contributor.authorGurjar, M
dc.contributor.authorMahmoodpoor, A
dc.contributor.authorAhmed, A
dc.contributor.authorMarsh, B
dc.contributor.authorElsaka, A
dc.contributor.authorSviri, S
dc.contributor.authorComellini, V
dc.contributor.authorRabha, A
dc.contributor.authorAhmed, H
dc.contributor.authorNamendys-Silva, S
dc.contributor.authorGhannam, A
dc.contributor.authorGroenendijk, M
dc.contributor.authorZegers, M
dc.contributor.authorde Lange, D
dc.contributor.authorCornet, A
dc.contributor.authorEvers, M
dc.contributor.authorHaas, L
dc.contributor.authorDormans, T
dc.contributor.authorDieperink, W
dc.contributor.authorRomundstad, L
dc.contributor.authorSjøbø, B
dc.contributor.authorAndersen, F
dc.contributor.authorStrietzel, H
dc.contributor.authorOlasveengen, T
dc.contributor.authorHahn, M
dc.contributor.authorCzuczwar, M
dc.contributor.authorGawda, R
dc.contributor.authorKlimkiewicz, J
dc.contributor.authorSantos, ML
dc.contributor.authorGordinho, A
dc.contributor.authorSantos, H
dc.contributor.authorAssis, R
dc.contributor.authorOliveira, AI
dc.contributor.authorBadawy, M
dc.contributor.authorPerez-Torres, D
dc.contributor.authorGomà, G
dc.contributor.authorVillamayor, M
dc.contributor.authorMira, A
dc.contributor.authorCubero, P
dc.contributor.authorRivera, S
dc.contributor.authorTomasa, T
dc.contributor.authorIglesias, D
dc.contributor.authorVázquez, E
dc.contributor.authorAldecoa, C
dc.contributor.authorFerreira, A
dc.contributor.authorZalba-Etayo, B
dc.contributor.authorCanas-Perez, I
dc.contributor.authorTamayo-Lomas, L
dc.contributor.authorDiaz-Rodriguez, C
dc.contributor.authorSancho, S
dc.contributor.authorPriego, J
dc.contributor.authorAbualqumboz, E
dc.contributor.authorHilles, M
dc.contributor.authorSaleh, M
dc.contributor.authorBen-Hamouda, N
dc.contributor.authorRoberti, A
dc.contributor.authorDullenkopf, A
dc.contributor.authorFleury, Y
dc.contributor.authorPinto, B
dc.contributor.authorSchefold, J
dc.contributor.authorAl-Sadaw, M
dc.date.accessioned2023-08-11T14:58:08Z
dc.date.available2023-08-11T14:58:08Z
dc.date.issued2022-04
dc.description.abstractPurpose: The number of patients ≥ 80 years admitted into critical care is increasing. Coronavirus disease 2019 (COVID-19) added another challenge for clinical decisions for both admission and limitation of life-sustaining treatments (LLST). We aimed to compare the characteristics and mortality of very old critically ill patients with or without COVID-19 with a focus on LLST. Methods: Patients 80 years or older with acute respiratory failure were recruited from the VIP2 and COVIP studies. Baseline patient characteristics, interventions in intensive care unit (ICU) and outcomes (30-day survival) were recorded. COVID patients were matched to non-COVID patients based on the following factors: age (± 2 years), Sequential Organ Failure Assessment (SOFA) score (± 2 points), clinical frailty scale (± 1 point), gender and region on a 1:2 ratio. Specific ICU procedures and LLST were compared between the cohorts by means of cumulative incidence curves taking into account the competing risk of discharge and death. Results: 693 COVID patients were compared to 1393 non-COVID patients. COVID patients were younger, less frail, less severely ill with lower SOFA score, but were treated more often with invasive mechanical ventilation (MV) and had a lower 30-day survival. 404 COVID patients could be matched to 666 non-COVID patients. For COVID patients, withholding and withdrawing of LST were more frequent than for non-COVID and the 30-day survival was almost half compared to non-COVID patients. Conclusion: Very old COVID patients have a different trajectory than non-COVID patients. Whether this finding is due to a decision policy with more active treatment limitation or to an inherent higher risk of death due to COVID-19 is unclear.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationIntensive Care Med . 2022 Apr;48(4):435-447.pt_PT
dc.identifier.doi10.1007/s00134-022-06642-zpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/4642
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.subjectHSJ UCIpt_PT
dc.subjectHumanspt_PT
dc.subjectCOVID-19* / therapypt_PT
dc.subjectCritical Carept_PT
dc.subjectCritical Illnesspt_PT
dc.subjectIntensive Care Unitspt_PT
dc.subjectRespiratory Insufficiency* / therapypt_PT
dc.subjectSARS-CoV-2pt_PT
dc.titleIncreased 30-Day Mortality in Very Old ICU Patients with COVID-19 Compared to Patients with Respiratory Failure without COVID-19pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage447pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage435pt_PT
oaire.citation.titleIntensive Care Medicinept_PT
oaire.citation.volume48pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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