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Impact of Time‐to‐Surgery on Outcomes of Patients Undergoing Curative‐Intent Liver Resection for BCLC‐0, A and B Hepatocellular Carcinoma

2021Journal article Unknown
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dc.contributor.authorTsilimigras, DI
dc.contributor.authorHyer, JM
dc.contributor.authorDiaz, A
dc.contributor.authorMoris, D
dc.contributor.authorBagante, F
dc.contributor.authorRatti, F
dc.contributor.authorPinto Marques, H
dc.contributor.authorSoubrane, O
dc.contributor.authorLam, V
dc.contributor.authorPoultsides, GA
dc.contributor.authorPopescu, I
dc.contributor.authorAlexandrescu, S
dc.contributor.authorMartel, G
dc.contributor.authorWorkneh, A
dc.contributor.authorGuglielmi, A
dc.contributor.authorHugh, T
dc.contributor.authorAldrighetti, L
dc.contributor.authorEndo, I
dc.contributor.authorPawlik, TM
dc.date.accessioned2023-01-31T10:46:39Z
dc.date.available2023-01-31T10:46:39Z
dc.date.issued2021
dc.description.abstractBackground: The impact of a prolonged time-to-surgery (TTS) among patients with resectable hepatocellular carcinoma (HCC) is not well defined. Methods: Patients who underwent curative-intent hepatectomy for BCLC-0, A and B HCC between 2000 and 2017 were identified using a multi-institutional database. The impact of prolonged TTS on overall survival (OS) and disease-free survival (DFS) was examined. Results: Among 775 patients who underwent resection for HCC, 537 (69.3%) had early surgery (TTS < 90 days) and 238 (30.7%) patients had a delayed surgery (TTS ≥ 90 days). Patient- and tumor-related characteristics were similar between the two groups except for a higher proportion of patients undergoing major liver resection in the early surgery group (31.3% vs. 23.8%, p = .04). The percentage of patients with delayed surgery varied from 8.8% to 59.1% among different centers (p < .001). Patients with TTS < 90 days had similar 5-year OS (63.7% vs. 64.9; p = .79) and 5-year DFS (33.5% vs. 42.4; p = .20) with that of patients with TTS ≥ 90 days. On multivariable analysis, delayed surgery was not associated with neither worse OS (BCLC-0/A: adjusted hazards ratio [aHR] = 0.90; 95% confidence interval [CI]: 0.65-1.25 and BCLC-B: aHR = 0.72; 95%CI: 0.30-1.74) nor DFS (BCLC-0/A: aHR = 0.78; 95%CI: 0.60-1.01 and BCLC-B: aHR = 0.67; 95% CI: 0.36-1.25). Conclusion: Approximately one in three patients diagnosed with resectable HCC had a prolonged TTS. Delayed surgery was not associated with worse outcomes among patients with resectable HCC.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Surg Oncol . 2021 Feb;123(2):381-388pt_PT
dc.identifier.doi10.1002/jso.26297pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/4368
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.subjectAgedpt_PT
dc.subjectFemalept_PT
dc.subjectMalept_PT
dc.subjectHumanspt_PT
dc.subjectCarcinoma, Hepatocellular / mortality*pt_PT
dc.subjectHCC CHBPTpt_PT
dc.subjectCarcinoma, Hepatocellular / pathology
dc.subjectCarcinoma, Hepatocellular / surgery
dc.subjectDatabases, Factual
dc.subjectFollow-Up Studies
dc.subjectHepatectomy / mortality*
dc.subjectLiver Neoplasms / mortality*
dc.subjectLiver Neoplasms / pathology
dc.subjectLiver Neoplasms / surgery
dc.subjectMiddle Aged
dc.subjectNeoplasm Staging
dc.subjectRetrospective Studies
dc.subjectSurvival Rate
dc.subjectTime-to-Treatment / statistics & numerical data*
dc.titleImpact of Time‐to‐Surgery on Outcomes of Patients Undergoing Curative‐Intent Liver Resection for BCLC‐0, A and B Hepatocellular Carcinomapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage388pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage381pt_PT
oaire.citation.titleJournal of Surgical Oncologypt_PT
oaire.citation.volume123pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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