Publication
Candidemia in Acute Leukemia Patients
| dc.contributor.author | Ribeiro, P | |
| dc.contributor.author | Botelho de Sousa, A | |
| dc.contributor.author | Aveiro, F | |
| dc.contributor.author | Nunes, O | |
| dc.contributor.author | Fernandes, JP | |
| dc.contributor.author | Gouveia, J | |
| dc.date.accessioned | 2011-06-03T15:59:45Z | |
| dc.date.available | 2011-06-03T15:59:45Z | |
| dc.date.issued | 1997 | |
| dc.description.abstract | Fungal infections are an important cause of morbidity and mortality in patients with acute leukemia (AL). Candidemia, once rare, is now a common nosocomial infection because of the intensity of chemotherapy, prolonged neutropenia, administration of broad-spectrum antibiotics and use of central venous catheters (CVC). We retrospectively identified patients treated for AL from 6/86 to 6/95 who also had candidemia. We describe 28 patients (incidence 6.3%) with a median age of 39 years, 24 of whom were on remission induction and 4 on postremission chemotherapy. All patients had CVC and empiric antimicrobial therapy, 4 had been given prophylactic antifungal drugs, and 2 had parenteral nutrition. Neutropenia was profound (median leukocyte nadir 200/microliters, median duration 19 days). Candida was isolated in blood cultures 10 days (median) after the start of neutropenia. The clinical presentation included fever (100%), respiratory symptoms (71.4%), skin lesions (39.2%) and septic shock (17.8%). Amphotericin B was given to 17 patients and liposomal amphotericin to 5 patients. Infection resolved in 18 patients (64.2%). 10 of whom were in complete remission. Mortality from candidemia was 17.8% (5/28). In conclusion, fungal infections are responsible for death in a significant number of patients. In our series treatment success was related to its rapid onset and to the recovery of neutropenia. | por |
| dc.identifier.citation | Support Care Cancer 1997 May;5(3):249-51 | por |
| dc.identifier.uri | http://hdl.handle.net/10400.17/225 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.publisher | Springer-Verlag | por |
| dc.subject | Doença Aguda | por |
| dc.subject | Adulto | por |
| dc.subject | Candidíase | por |
| dc.subject | Causalidade | por |
| dc.subject | Fungemia | por |
| dc.subject | Hospedeiro Imunocomprometido | por |
| dc.subject | Incidência | por |
| dc.subject | Leucemia | por |
| dc.subject | Estudos Retrospectivos | por |
| dc.subject | Factores de Risco | por |
| dc.title | Candidemia in Acute Leukemia Patients | por |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 251 | por |
| oaire.citation.startPage | 249 | por |
| oaire.citation.title | Supportive Care in Cancer | por |
| rcaap.rights | openAccess | por |
| rcaap.type | article | por |