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Profiling Persistent Asthma Phenotypes in Adolescents: A Longitudinal Diagnostic Evaluation from the INSPIRERS Studies

2021Journal article Open access
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dc.contributor.authorAmaral, R
dc.contributor.authorJácome, C
dc.contributor.authorAlmeida, R
dc.contributor.authorPereira, AM
dc.contributor.authorAlves-Correia, M
dc.contributor.authorMendes, S
dc.contributor.authorRodrigues, JC
dc.contributor.authorCarvalho, J
dc.contributor.authorAraújo, L
dc.contributor.authorCosta, A
dc.contributor.authorSilva, A
dc.contributor.authorTeixeira, MF
dc.contributor.authorFerreira-Magalhães, M
dc.contributor.authorAlves, RR
dc.contributor.authorMoreira, AS
dc.contributor.authorFernandes, RM
dc.contributor.authorFerreira, R
dc.contributor.authorLeiria-Pinto, P
dc.contributor.authorNeuparth, N
dc.contributor.authorBordalo, D
dc.contributor.authorTodo Bom, A
dc.contributor.authorCálix, MJ
dc.contributor.authorFerreira, T
dc.contributor.authorGomes, J
dc.contributor.authorVidal, C
dc.contributor.authorMendes, A
dc.contributor.authorVasconcelos, MJ
dc.contributor.authorSilva, PM
dc.contributor.authorFerraz, J
dc.contributor.authorMorête, A
dc.contributor.authorPinto, CS
dc.contributor.authorSantos, N
dc.contributor.authorLoureiro, CC
dc.contributor.authorArrobas, A
dc.contributor.authorMarques, ML
dc.contributor.authorLozoya, C
dc.contributor.authorLopes, C
dc.contributor.authorCardia, F
dc.contributor.authorLoureiro, CC
dc.contributor.authorCâmara, R
dc.contributor.authorVieira, I
dc.contributor.authorSilva, S
dc.contributor.authorSilva, E
dc.contributor.authorRodrigues, N
dc.contributor.authorFonseca, JA
dc.date.accessioned2021-06-24T09:25:54Z
dc.date.available2021-06-24T09:25:54Z
dc.date.issued2021
dc.description.abstractWe aimed to identify persistent asthma phenotypes among adolescents and to evaluate longitudinally asthma-related outcomes across phenotypes. Adolescents (13-17 years) from the prospective, observational, and multicenter INSPIRERS studies, conducted in Portugal and Spain, were included (n = 162). Latent class analysis was applied to demographic, environmental, and clinical variables, collected at a baseline medical visit. Longitudinal differences in clinical variables were assessed at a 4-month follow-up telephone contact (n = 128). Three classes/phenotypes of persistent asthma were identified. Adolescents in class 1 (n = 87) were highly symptomatic at baseline and presented the highest number of unscheduled healthcare visits per month and exacerbations per month, both at baseline and follow-up. Class 2 (n = 32) was characterized by female predominance, more frequent obesity, and uncontrolled upper/lower airways symptoms at baseline. At follow-up, there was a significant increase in the proportion of controlled lower airway symptoms (p < 0.001). Class 3 (n = 43) included mostly males with controlled lower airways symptoms; at follow-up, while keeping symptom control, there was a significant increase in exacerbations/month (p = 0.015). We have identified distinct phenotypes of persistent asthma in adolescents with different patterns in longitudinal asthma-related outcomes, supporting the importance of profiling asthma phenotypes in predicting disease outcomes that might inform targeted interventions and reduce future risk.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationInt J Environ Res Public Health. 2021;18(3):1015pt_PT
dc.identifier.doi10.3390/ijerph18031015pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/3752
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPI - Multidisciplinary Digital Publishing Institutept_PT
dc.subjectAdolescentpt_PT
dc.subjectFemalept_PT
dc.subjectHumanspt_PT
dc.subjectMalept_PT
dc.subjectPhenotypept_PT
dc.subjectPortugalpt_PT
dc.subjectProspective Studiespt_PT
dc.subjectSpainpt_PT
dc.subjectAsthmapt_PT
dc.subjectHDE ALERpt_PT
dc.titleProfiling Persistent Asthma Phenotypes in Adolescents: A Longitudinal Diagnostic Evaluation from the INSPIRERS Studiespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue3pt_PT
oaire.citation.startPage1015pt_PT
oaire.citation.titleInternational journal of environmental research and public healthpt_PT
oaire.citation.volume18pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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