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SAPHO: Has the Time Come for Tailored Therapy?

2020-01Journal article Open access
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dc.contributor.authorFigueiredo, AS
dc.contributor.authorOliveira, AL
dc.contributor.authorCaetano, A
dc.contributor.authorMoraes-Fontes, MF
dc.date.accessioned2020-05-22T14:17:30Z
dc.date.available2020-05-22T14:17:30Z
dc.date.issued2020-01
dc.description.abstractSAPHO (synovitis, acne, pustulosis, hyperostosis and osteitis) syndrome is a heterogeneous condition combining osteoarticular and cutaneous manifestations. Conventional treatments are mostly ineffective. We hereby report two patients, the first with an aggressive form of disease and the second with an incomplete response to two different anti-TNF-α agents. Both were successfully treated with tocilizumab and ustekinumab, respectively, over a long period of time. A narrative review of a biological therapy in SAPHO syndrome yielded very little information on the specific use of these agents. We highlight the advantages of personalising therapy and describe emerging promising treatments for this disease.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationClin Rheumatol . 2020 Jan;39(1):177-187pt_PT
dc.identifier.doi10.1007/s10067-019-04675-2pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/3467
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.subjectAcquired Hyperostosis Syndrome / diagnosis*pt_PT
dc.subjectAcquired Hyperostosis Syndrome / drug therapy*pt_PT
dc.subjectAdultpt_PT
dc.subjectFemalept_PT
dc.subjectMalept_PT
dc.subjectHCC IMApt_PT
dc.subjectHCC DAUTOIMpt_PT
dc.subjectHumans
dc.subjectAcquired Hyperostosis Syndrome / immunology
dc.subjectAntibodies, Monoclonal, Humanized / therapeutic use
dc.subjectBone and Bones / diagnostic imaging*
dc.subjectMiddle Aged
dc.subjectRadionuclide Imaging
dc.subjectTreatment Outcome
dc.subjectTumor Necrosis Factor Inhibitors / therapeutic use*
dc.subjectUstekinumab / therapeutic use
dc.titleSAPHO: Has the Time Come for Tailored Therapy?pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage187pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage177pt_PT
oaire.citation.titleClinical rheumatologypt_PT
oaire.citation.volume39pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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