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Prognostic Utility of Albumin-Bilirubin Grade for Short- and Long-Term Outcomes Following Hepatic Resection for Intrahepatic Cholangiocarcinoma: a Multi-Institutional Analysis of 706 Patients

2019-08Journal article Open access
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dc.contributor.authorTsilimigras, D
dc.contributor.authorHyer, J
dc.contributor.authorMoris, D
dc.contributor.authorSahara, K
dc.contributor.authorBagante, F
dc.contributor.authorGuglielmi, A
dc.contributor.authorAldrighetti, L
dc.contributor.authorAlexandrescu, S
dc.contributor.authorPinto Marques, H
dc.contributor.authorShen, F
dc.contributor.authorKoerkamp, B
dc.contributor.authorEndo, I
dc.contributor.authorPawlik, T
dc.date.accessioned2021-04-15T14:46:02Z
dc.date.available2021-04-15T14:46:02Z
dc.date.issued2019-08
dc.description.abstractBackground: The objective of the current study was to define the impact of albumin-bilirubin (ALBI) grade on short- as well as long-term outcomes among patients with intrahepatic cholangiocarcinoma (ICC). Methods: Patients who underwent hepatectomy for ICC between 1990 and 2016 were identified using an international multi-institutional database. Clinicopathologic factors including ALBI score were assessed using bivariate and multivariable analyses, as well as standard survival analyses. Results: Among 706 patients, 453 (64.2%) patients had ALBI grade 1, 231 (32.7%) ALBI grade 2, and 22 (3.1%) had ALBI grade 3. After adjusting for all competing factors, patients with ALBI grade 2/3 had higher odds of a prolonged length-of-stay (>10 days, odds ratio [OR] = 2.37, 95% confidence interval [CI]:1.47-3.80), perioperative transfusion (OR = 2.15, 95% CI:1.45-3.18) and 90-day mortality (OR = 2.50, 95% CI:1.16-5.38). Median and 5-year overall survival (OS) for the entire cohort was 41.5 months (IQR:15.7-107.8) and 39.8%, respectively. Of note, median OS incrementally worsened with increased ALBI grade: grade 1, 49.6 months (IQR:18.3-NR) vs grade 2, 29.6 months (IQR:12.6-98.4) vs grade 3, 16.9 months (IQR:6.5-32.4; P < 0.001). On multivariable analysis, higher ALBI grade remained associated with higher hazards of death (grade 2/3: hazard ratio = 1.36, 95% CI:1.04-1.78). Conclusion: The ALBI score was associated with both short- and long-term outcomes following resection for ICC and could prove a useful surrogate marker to identify patients at risk for adverse outcomes.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Surg Oncol. 2019 Aug;120(2):206-213.pt_PT
dc.identifier.doi10.1002/jso.25486pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/3660
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.subjectAgedpt_PT
dc.subjectBile Duct Neoplasmspt_PT
dc.subjectBilirubinpt_PT
dc.subjectBiomarkerspt_PT
dc.subjectCholangiocarcinomapt_PT
dc.subjectFemalept_PT
dc.subjectHumanspt_PT
dc.subjectMalept_PT
dc.subjectMiddle Agedpt_PT
dc.subjectPredictive Value of Testspt_PT
dc.subjectRetrospective Studiespt_PT
dc.subjectSerum Albuminpt_PT
dc.subjectSurvival Ratept_PT
dc.subjectTreatment Outcomept_PT
dc.subjectBile Ducts, Intrahepaticpt_PT
dc.subjectHepatectomypt_PT
dc.subjectHCC CIRpt_PT
dc.titlePrognostic Utility of Albumin-Bilirubin Grade for Short- and Long-Term Outcomes Following Hepatic Resection for Intrahepatic Cholangiocarcinoma: a Multi-Institutional Analysis of 706 Patientspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage213pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage206pt_PT
oaire.citation.titleJournal of Surgical Oncologypt_PT
oaire.citation.volume120pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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