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Efficacy of Narrowband UVB vs. PUVA in Patients with Early-Stage Mycosis Fungoides

2010-06Journal article Open access
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dc.contributor.authorPonte, P
dc.contributor.authorSerrão, V
dc.contributor.authorApetato, M
dc.date.accessioned2017-03-29T15:41:32Z
dc.date.available2017-03-29T15:41:32Z
dc.date.issued2010-06
dc.description.abstractINTRODUCTION: Mycosis fungoides (MF) is a non-Hodgkin's T-cell lymphoma of the skin that often begins as limited patches and plaques with slow progression to systemic involvement. Narrowband ultraviolet (UV) B therapy has been proven to be an effective short-term treatment modality for clearing patch-stage MF. The effect of psoralen plus long-wave ultraviolet A (PUVA) in the treatment of patch- and plaque-type MF has also been thoroughly documented. OBJECTIVES: The purpose of this study was to compare the efficacy and safety of narrowband UVB and PUVA in patients with early-stage MF. METHODS: We analysed the response to treatment, relapse-free survival and irradiation dose in 114 patients with histologically confirmed early-stage MF (stage IA, IB and IIA). RESULTS: A total of 95 patients were treated with PUVA (83.3%) and 19 with narrowband UVB (16.7%). With PUVA, 59 patients (62.1%) had a complete response (CR), 24 (25.3%) had a partial response (PR) and 12 (12.6%) had a failed response. Narrowband UVB led to CR in 12 (68.4%) patients, PR in 5 (26.3%) patients and a failed response in 1 (5.3%) patient. There were no differences in terms of time to relapse between patients treated with PUVA and those treated with narrowband UVB (11.5 vs. 14.0 months respectively; P = 0.816). No major adverse reactions were attributed to the treatment. CONCLUSIONS: Our results confirm that phototherapy is a safe, effective and well-tolerated, first-line therapy in patients with early-stage cutaneous T-cell lymphoma, with prolonged disease-free remissions being achieved. It suggests that narrowband UVB is at least as effective as PUVA for treatment of early-stage MF.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Eur Acad Dermatol Venereol. 2010 Jun;24(6):716-21pt_PT
dc.identifier.doi10.1111/j.1468-3083.2009.03500.xpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/2653
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.subjectAdultpt_PT
dc.subjectAgedpt_PT
dc.subjectAged, 80 and overpt_PT
dc.subjectDose-Response Relationship, Radiationpt_PT
dc.subjectFemalept_PT
dc.subjectHumanspt_PT
dc.subjectKaplan-Meier Estimatept_PT
dc.subjectLymphoma, T-Cell, Cutaneouspt_PT
dc.subjectMalept_PT
dc.subjectMiddle Agedpt_PT
dc.subjectMycosis Fungoidespt_PT
dc.subjectNeoplasm Stagingpt_PT
dc.subjectRetrospective Studiespt_PT
dc.subjectSkin Neoplasmspt_PT
dc.subjectTreatment Outcomept_PT
dc.subjectPUVA Therapypt_PT
dc.subjectUltraviolet Therapypt_PT
dc.subjectHSAC DERpt_PT
dc.titleEfficacy of Narrowband UVB vs. PUVA in Patients with Early-Stage Mycosis Fungoidespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage721pt_PT
oaire.citation.issue6pt_PT
oaire.citation.startPage716pt_PT
oaire.citation.titleJournal of the European Academy of Dermatology and Venereologypt_PT
oaire.citation.volume24pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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