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Acute Cardiovascular Manifestations in 286 Children With Multisystem Inflammatory Syndrome Associated With COVID-19 Infection in Europe

2021-01Journal article Open access
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dc.contributor.authorValverde, I
dc.contributor.authorSingh, Y
dc.contributor.authorSanchez-de-Toledo, J
dc.contributor.authorTheocharis, P
dc.contributor.authorChikermane, A
dc.contributor.authorDi Filippo, S
dc.contributor.authorKuciñska, B
dc.contributor.authorMannarino, S
dc.contributor.authorTamariz-Martel, A
dc.contributor.authorGutierrez-Larraya, F
dc.contributor.authorSoda, G
dc.contributor.authorVandekerckhove, K
dc.contributor.authorGonzalez-Barlatay, F
dc.contributor.authorMcMahon, C
dc.contributor.authorMarcora, S
dc.contributor.authorNapoleone, C
dc.contributor.authorDuong, P
dc.contributor.authorTuo, G
dc.contributor.authorDeri, A
dc.contributor.authorNepali, G
dc.contributor.authorIlina, M
dc.contributor.authorCiliberti, P
dc.contributor.authorMiller, O
dc.contributor.authorIriart, X
dc.contributor.authorHubrechts, J
dc.contributor.authorKuipers, I
dc.contributor.authorSousa, A
dc.contributor.authorDonti, A
dc.contributor.authorSharpe, A
dc.contributor.authorReinhardt, Z
dc.contributor.authorCairello, F
dc.contributor.authorDe Wolf, D
dc.contributor.authorVieira, M
dc.contributor.authorLazea, C
dc.contributor.authorGran, F
dc.contributor.authorMedrano-Lopez, C
dc.contributor.authorOrtiz-Garrido, A
dc.contributor.authorVukomanovic, V
dc.contributor.authorBrent, B
dc.contributor.authorMilanesi, O
dc.contributor.authorDewals, W
dc.contributor.authorManso, B
dc.contributor.authorValsangiacomo-Buchel, E
dc.contributor.authorFrancisco, A
dc.contributor.authorSeghaye, MC
dc.contributor.authorLoeckx, I
dc.contributor.authorRodriguez-Gonzalez, M
dc.contributor.authorReyGarcía, S
dc.contributor.authorZiesenitz, V
dc.contributor.authorBordin, G
dc.contributor.authorDoros, G
dc.contributor.authorGrangl, G
dc.contributor.authorFadl, S
dc.contributor.authorPerminow, K
dc.contributor.authorCenteno, F
dc.contributor.authorPinto, F
dc.contributor.authorNiemelä, J
dc.contributor.authorKanthimathinathan, H
dc.contributor.authorRandanne, P
dc.contributor.authorNiszczota, C
dc.contributor.authorZuccotti, G
dc.contributor.authorGordillo, I
dc.contributor.authorObeyasekhara, M
dc.contributor.authorArmstrong, C
dc.contributor.authorButler, K
dc.contributor.authorCiuffreda, M
dc.contributor.authorVillar, AM
dc.contributor.authorPappula, N
dc.contributor.authorCaorsi, R
dc.contributor.authorSingh, D
dc.contributor.authorDurairaj, S
dc.contributor.authorMcLeod, K
dc.contributor.authorCalcagni, G
dc.contributor.authorQuizad, Y
dc.contributor.authorGewillig, M
dc.contributor.authorKuijpers, T
dc.contributor.authorAtaide, R
dc.contributor.authorFabi, M
dc.contributor.authorBharucha, T
dc.contributor.authorAbbas, K
dc.contributor.authorMagrass, S
dc.contributor.authorWong, J
dc.contributor.authorIacob, D
dc.contributor.authorBalcells, J
dc.contributor.authorGilVillanueva, N
dc.contributor.authorCuenca-Peiro, V
dc.contributor.authorCerovi, I
dc.contributor.authorSarfatt, A
dc.contributor.authorZaqout, M
dc.contributor.authorSanchez-Valderrabanos, E
dc.contributor.authorKelly-Geyer, J
dc.contributor.authorDiogo, F
dc.contributor.authorCajgfinger, N
dc.contributor.authorFrançoise, M
dc.contributor.authorRueda-Nuñez, F
dc.contributor.authorGorenflo, M
dc.contributor.authorGrison, A
dc.contributor.authorMihailov, D
dc.contributor.authorKoestenberger, M
dc.contributor.authorAlcalde, C
dc.contributor.authorTrigo, C
dc.contributor.authorArola, A
dc.contributor.authorHanseus, K
dc.date.accessioned2023-12-20T16:06:00Z
dc.date.available2023-12-20T16:06:00Z
dc.date.issued2021-01
dc.description.abstractBackground: The aim of the study was to document cardiovascular clinical findings, cardiac imaging, and laboratory markers in children presenting with the novel multisystem inflammatory syndrome associated with coronavirus disease 2019 (COVID-19) infection. Methods: This real-time internet-based survey has been endorsed by the Association for European Paediatric and Congenital Cardiologists Working Groups for Cardiac Imaging and Cardiovascular Intensive Care. Children 0 to 18 years of age admitted to a hospital between February 1 and June 6, 2020, with a diagnosis of an inflammatory syndrome and acute cardiovascular complications were included. Results: A total of 286 children from 55 centers in 17 European countries were included. The median age was 8.4 years (interquartile range, 3.8-12.4 years) and 67% were boys. The most common cardiovascular complications were shock, cardiac arrhythmias, pericardial effusion, and coronary artery dilatation. Reduced left ventricular ejection fraction was present in over half of the patients, and a vast majority of children had raised cardiac troponin when checked. The biochemical markers of inflammation were raised in most patients on admission: elevated C-reactive protein, serum ferritin, procalcitonin, N-terminal pro B-type natriuretic peptide, interleukin-6 level, and D-dimers. There was a statistically significant correlation between degree of elevation in cardiac and biochemical parameters and the need for intensive care support (P<0.05). Polymerase chain reaction for severe acute respiratory syndrome coronavirus 2 was positive in 33.6%, whereas immunoglobulin M and immunoglobulin G antibodies were positive in 15.7% cases and immunoglobulin G in 43.6% cases, respectively, when checked. One child in the study cohort died. Conclusions: Cardiac involvement is common in children with multisystem inflammatory syndrome associated with the Covid-19 pandemic. The majority of children have significantly raised levels of N-terminal pro B-type natriuretic peptide, ferritin, D-dimers, and cardiac troponin in addition to high C-reactive protein and procalcitonin levels. In comparison with adults with COVID-19, mortality in children with multisystem inflammatory syndrome associated with COVID-19 is uncommon despite multisystem involvement, very elevated inflammatory markers, and the need for intensive care support.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCirculation . 2021 Jan 5;143(1):21-32.pt_PT
dc.identifier.doi10.1161/CIRCULATIONAHA.120.050065pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/4763
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherAmerican Heart Associationpt_PT
dc.subjectHSM CAR PEDpt_PT
dc.subjectAdolescentpt_PT
dc.subjectAntibodies, Viral / bloodpt_PT
dc.subjectArrhythmias, Cardiac* / bloodpt_PT
dc.subjectArrhythmias, Cardiac* / epidemiologypt_PT
dc.subjectArrhythmias, Cardiac* / etiologypt_PT
dc.subjectArrhythmias, Cardiac* / therapypt_PT
dc.subjectBiomarkers / bloodpt_PT
dc.subjectC-Reactive Protein / metabolismpt_PT
dc.subjectCOVID-19* / bloodpt_PT
dc.subjectCOVID-19* / complicationspt_PT
dc.subjectCOVID-19* / epidemiologypt_PT
dc.subjectChild, Preschoolpt_PT
dc.subjectChildpt_PT
dc.subjectCOVID-19* / therapypt_PT
dc.subjectFemalept_PT
dc.subjectHumanspt_PT
dc.subjectEurope / epidemiologypt_PT
dc.subjectMalept_PT
dc.subjectInfantpt_PT
dc.subjectFerritins / bloodpt_PT
dc.subjectFibrin Fibrinogen Degradation Products / metabolismpt_PT
dc.subjectImmunoglobulin G / bloodpt_PT
dc.subjectImmunoglobulin M / bloodpt_PT
dc.subjectInterleukin-6 / bloodpt_PT
dc.subjectNatriuretic Peptide, Brain / bloodpt_PT
dc.subjectPandemicspt_PT
dc.subjectPeptide Fragments / bloodpt_PT
dc.subjectPericardial Effusion* / epidemiologypt_PT
dc.subjectPericardial Effusion* / bloodpt_PT
dc.subjectPericardial Effusion* / etiologypt_PT
dc.subjectPericardial Effusion* / therapypt_PT
dc.subjectSARS-CoV-2*pt_PT
dc.subjectShock* / bloodpt_PT
dc.subjectShock* / epidemiologypt_PT
dc.subjectShock* / etiologypt_PT
dc.subjectShock* / therapypt_PT
dc.subjectSystemic Inflammatory Response Syndrome* / bloodpt_PT
dc.subjectSystemic Inflammatory Response Syndrome* / complicationspt_PT
dc.subjectSystemic Inflammatory Response Syndrome* / epidemiologypt_PT
dc.subjectSystemic Inflammatory Response Syndrome* / therapypt_PT
dc.titleAcute Cardiovascular Manifestations in 286 Children With Multisystem Inflammatory Syndrome Associated With COVID-19 Infection in Europept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage32pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage21pt_PT
oaire.citation.titleCirculationpt_PT
oaire.citation.volume143pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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