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Sex-Specific Outcome Disparities in Very Old Patients Admitted to Intensive Care Medicine: a Propensity Matched Analysis

2020-10Journal article Open access
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dc.contributor.authorWernly, B
dc.contributor.authorRomano Bruno, R
dc.contributor.authorKelm, M
dc.contributor.authorBoumendil, A
dc.contributor.authorMorandi, A
dc.contributor.authorAndersen, F
dc.contributor.authorArtigas, A
dc.contributor.authorFinazzi, S
dc.contributor.authorCecconi, M
dc.contributor.authorChristensen, S
dc.contributor.authorFaraldi, L
dc.contributor.authorLichtenauer, M
dc.contributor.authorMuessig, J
dc.contributor.authorMarsh, B
dc.contributor.authorMoreno, R
dc.contributor.authorOeyen, S
dc.contributor.authorÖhman, C
dc.contributor.authorBollen Pinto, B
dc.contributor.authorSoliman, I
dc.contributor.authorSzczeklik, W
dc.contributor.authorNiederseer, D
dc.contributor.authorValentin, A
dc.contributor.authorWatson, X
dc.contributor.authorLeaver, S
dc.contributor.authorBoulanger, C
dc.contributor.authorWalther, S
dc.contributor.authorSchefold, J
dc.contributor.authorJoannidis, M
dc.contributor.authorNalapko, Y
dc.contributor.authorElhadi, M
dc.contributor.authorFjølner, J
dc.contributor.authorZafeiridis, T
dc.contributor.authorDe Lange, D
dc.contributor.authorGuidet, B
dc.contributor.authorFlaatten, H
dc.contributor.authorJung, C
dc.date.accessioned2024-02-22T15:11:58Z
dc.date.available2024-02-22T15:11:58Z
dc.date.issued2020-10
dc.description.abstractFemale and male very elderly intensive patients (VIPs) might differ in characteristics and outcomes. We aimed to compare female versus male VIPs in a large, multinational collective of VIPs with regards to outcome and predictors of mortality. In total, 7555 patients were included in this analysis, 3973 (53%) male and 3582 (47%) female patients. The primary endpoint was 30-day-mortality. Baseline characteristics, data on management and geriatric scores including frailty assessed by Clinical Frailty Scale (CFS) were documented. Two propensity scores (for being male) were obtained for consecutive matching, score 1 for baseline characteristics and score 2 for baseline characteristics and ICU management. Male VIPs were younger (83 ± 5 vs. 84 ± 5; p < 0.001), less often frail (CFS > 4; 38% versus 49%; p < 0.001) but evidenced higher SOFA (7 ± 6 versus 6 ± 6 points; p < 0.001) scores. After propensity score matching, no differences in baseline characteristics could be observed. In the paired analysis, the mortality in male VIPs was higher (mean difference 3.34% 95%CI 0.92-5.76%; p = 0.007) compared to females. In both multivariable logistic regression models correcting for propensity score 1 (aOR 1.15 95%CI 1.03-1.27; p = 0.007) and propensity score 2 (aOR 1.15 95%CI 1.04-1.27; p = 0.007) male sex was independently associated with higher odds for 30-day-mortality. Of note, male gender was not associated with ICU mortality (OR 1.08 95%CI 0.98-1.19; p = 0.14). Outcomes of elderly intensive care patients evidenced independent sex differences. Male sex was associated with adverse 30-day-mortality but not ICU-mortality. Further research to identify potential sex-specific risk factors after ICU discharge is warranted.Trial registration: NCT03134807 and NCT03370692; Registered on May 1, 2017 https://clinicaltrials.gov/ct2/show/NCT03370692 .pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSci Rep . 2020 Oct 29;10(1):18671pt_PT
dc.identifier.doi10.1038/s41598-020-74910-3pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/4809
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherNature Publishing Grouppt_PT
dc.subjectHSJ UCIpt_PT
dc.subjectAgedpt_PT
dc.subjectAged, 80 and overpt_PT
dc.subjectCohort Studiespt_PT
dc.subjectFemalept_PT
dc.subjectHumanspt_PT
dc.subjectMalept_PT
dc.subjectCritical Care*pt_PT
dc.subjectPatient Admission*pt_PT
dc.subjectPropensity Scorept_PT
dc.subjectSex Factors*pt_PT
dc.subjectTreatment Outcome*pt_PT
dc.titleSex-Specific Outcome Disparities in Very Old Patients Admitted to Intensive Care Medicine: a Propensity Matched Analysispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue1pt_PT
oaire.citation.titleScientific Reportspt_PT
oaire.citation.volume10pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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