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Leydig Cell Tumour and Mature Ovarian Teratoma: Rare Androgen-Secreting Ovarian Tumours in Postmenopausal Women

2016-11-01Journal article Open access
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dc.contributor.authorPalha, A
dc.contributor.authorCortez, L
dc.contributor.authorTavares, AP
dc.contributor.authorAgapito, A
dc.date.accessioned2017-03-15T13:15:07Z
dc.date.available2017-03-15T13:15:07Z
dc.date.issued2016-11-01
dc.description.abstractAndrogen-secreting ovarian tumours are extremely rare accounting for <5% of all ovarian neoplasms. They are more frequent in postmenopausal women and should be suspected in the case of a rapid onset of androgenic symptoms. We report 4 cases of postmenopausal women who presented with signs of virilisation. All patients revealed increased serum levels of testosterone, normal dehydroepiandrosterone-sulfate and negative pelvic ultrasound for adnexal masses. An androgen-secreting ovarian tumour was suspected and all of them were submitted to bilateral oophorectomy. Histology confirmed the diagnosis of Leydig cell tumours in 3 patients and mature teratoma in 1. A successful response to surgery, which includes a decline in serum androgen levels and signs of hyperandrogenism, was observed in our patients. This case series demonstrates that androgen-secreting ovarian neoplasms may not be detectable by imaging studies, but should be considered in the differential diagnosis of all postmenopausal women with signs of hyperandrogenism.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBMJ Case Rep. 2016 Nov 1;2016. pii: bcr2016215985.pt_PT
dc.identifier.doi10.1136/bcr-2016-215985pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/2636
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBMJ Publishing Grouppt_PT
dc.subjectAgedpt_PT
dc.subjectAndrogens/bloodpt_PT
dc.subjectFemalept_PT
dc.subjectHumanspt_PT
dc.subjectLeydig Cell Tumor/complicationspt_PT
dc.subjectOvarian Neoplasms/complicationspt_PT
dc.subjectOvariectomypt_PT
dc.subjectPostmenopausept_PT
dc.subjectTeratoma/complicationspt_PT
dc.subjectVirilism/etiologypt_PT
dc.subjectAndrogens/secretionpt_PT
dc.subjectLeydig Cell Tumor/secretionpt_PT
dc.subjectLeydig Cell Tumor/surgerypt_PT
dc.subjectOvarian Neoplasms/secretionpt_PT
dc.subjectOvarian Neoplasms/surgerypt_PT
dc.subjectTeratoma/surgerypt_PT
dc.subjectTeratoma/secretionpt_PT
dc.subjectCHLC ENDpt_PT
dc.subjectCHLC CIRpt_PT
dc.titleLeydig Cell Tumour and Mature Ovarian Teratoma: Rare Androgen-Secreting Ovarian Tumours in Postmenopausal Womenpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPagebcr2016215985pt_PT
oaire.citation.titleBMJ Case Reportspt_PT
oaire.citation.volume2016pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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