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Regional White Matter Atrophy Correlates with Spike Activity in Encephalopathy Related to Status Epilepticus During Slow Sleep (ESES) After Early Thalamic Lesions

2020Journal article Open access
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dc.contributor.authorOliveira, AR
dc.contributor.authorNunes, RG
dc.contributor.authorFigueiredo, P
dc.contributor.authorDias, AI
dc.contributor.authorLeal, A
dc.date.accessioned2021-01-22T15:30:22Z
dc.date.available2021-01-22T15:30:22Z
dc.date.issued2020
dc.description.abstractEncephalopathy related to Status Epilepticus during slow Sleep (ESES) is an age-related, epileptic syndrome, which associates cognitive/behavioral disturbances with a peculiar pattern of spike activity. One promising line of research is the study of ESES in cases of early thalamic lesions. We studied 7 ESES patients with unilateral thalamic lesions using magnetic resonance imaging to assess regional white matter (WM) and thalamic nuclei volume differences, and long-term electroencephalogram recordings to localize the epileptogenic cortex. N170 event-related potentials were used to demonstrate the dysfunctional character of the WM abnormalities. Diffusion-weighted images in a subset of 4 patients were used to parcellate the thalamus and evaluate volume asymmetries, based on cortical connectivity. Large WM regional atrophy in the hemisphere with the thalamic lesion was associated with both cortical dysfunction and epileptic activity. A correlation was demonstrated between lesions in the pulvinar and the mediodorsal thalamic nuclei and WM atrophy of the corresponding cortical projection areas. We propose that these abnormalities are due to the widespread structural disconnection produced by the thalamic lesions associated to a yet unknown age-dependent factor. Further exploration of WM regional atrophy association with the spike activity in other etiologies could lend support to the cortical disconnection role in ESES genesis.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBrain Topogr . 2020 Sep;33(5):571-585pt_PT
dc.identifier.doi10.1007/s10548-020-00784-3pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/3541
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.subjectAtrophypt_PT
dc.subjectElectroencephalographypt_PT
dc.subjectHumanspt_PT
dc.subjectSleeppt_PT
dc.subjectBrain Diseasespt_PT
dc.subjectStatus Epilepticuspt_PT
dc.subjectWhite Matterpt_PT
dc.subjectHDE NEU PEDpt_PT
dc.titleRegional White Matter Atrophy Correlates with Spike Activity in Encephalopathy Related to Status Epilepticus During Slow Sleep (ESES) After Early Thalamic Lesionspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage585pt_PT
oaire.citation.issue5pt_PT
oaire.citation.startPage571pt_PT
oaire.citation.titleBrain topographypt_PT
oaire.citation.volume33pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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