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Improvement of Mineral and Bone Disorders After Renal Transplantation

2022-05Journal article Open access
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dc.contributor.authorFerreira, AC
dc.contributor.authorMendes, M
dc.contributor.authorSilva, C
dc.contributor.authorCotovio, P
dc.contributor.authorAires, I
dc.contributor.authorNavarro, D
dc.contributor.authorCaeiro, F
dc.contributor.authorRamos, R
dc.contributor.authorSalvador, R
dc.contributor.authorCorreia, B
dc.contributor.authorCabral, G
dc.contributor.authorNolasco, F
dc.contributor.authorFerreira, A
dc.date.accessioned2024-05-03T15:12:31Z
dc.date.available2024-05-03T15:12:31Z
dc.date.issued2022-05
dc.description.abstractBackground: Posttransplant mineral and bone diseases are causes of fractures, and their association with cardiovascular events is being studied. Methods: We analyzed the evolution of biochemical, histological, and imaging parameters pre- and 1 y post-renal transplantation in 69 patients and correlated mineral and bone findings with coronary calcifications. At inclusion and after 12 mo, clinical data and echocardiographic findings were recorded, and laboratory evaluations, radiography of the pelvis and hands, and bone biopsy were performed. Noncontrast cardiac computed tomography was performed during the second evaluation. Results: Serum levels of fibroblast growth factor 23 and sclerostin decreased in all patients, parathyroid hormone levels decreased in 89.8% of patients, bone alkaline phosphatase levels decreased in 68.1% of patients, and alpha-Klotho levels increased in 65.2% of patients. More than half of the patients presented with renal osteodystrophy at both biopsies, but histological findings improved: a significant transition from high to normal or low turnover and no significant differences in volume, mineralization defect, or cortical porosity at the 2 evaluations. Alpha-Klotho, sclerostin, and bone alkaline phosphatase shifts affect bone changes. Neither echocardiographic findings nor vascular calcification scores differed between the 2 points. Both the pretransplant period (dialysis vintage, sclerostin, and low bone volume at baseline) and the maintenance of abnormalities in the posttransplant period (high turnover posttransplant) were the most reliable predictors of the severity of the coronary calcification percentile. Conclusions: Renal transplantation improved bone and mineral abnormalities. The pretransplant period determines the severity of calcification.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationTransplantation . 2022 May 1;106(5):e251-e261.pt_PT
dc.identifier.doi10.1097/TP.0000000000004099pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/4891
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherLippincott. Williams & Wilkinspt_PT
dc.subjectHCC NEFpt_PT
dc.subjectHSM CARpt_PT
dc.subjectAlkaline Phosphatasept_PT
dc.subjectBone Densitypt_PT
dc.subjectChronic Kidney Disease-Mineral and Bone Disorder* / diagnostic imagingpt_PT
dc.subjectHumanspt_PT
dc.subjectFemalept_PT
dc.subjectMalept_PT
dc.subjectChronic Kidney Disease-Mineral and Bone Disorder* / etiologypt_PT
dc.subjectKidney Transplantation* / adverse effectspt_PT
dc.subjectParathyroid Hormonept_PT
dc.subjectMineralspt_PT
dc.subjectRenal Dialysispt_PT
dc.titleImprovement of Mineral and Bone Disorders After Renal Transplantationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPagee261pt_PT
oaire.citation.issue5pt_PT
oaire.citation.startPagee251pt_PT
oaire.citation.titleTransplantationpt_PT
oaire.citation.volume106pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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