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Current Evidence on the Impact of Medication Optimization or Pharmacological Interventions on Frailty or Aspects of Frailty: a Systematic Review of Randomized Controlled Trials

2020-01Journal article Open access
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dc.contributor.authorPazan, F
dc.contributor.authorPetrovic, M
dc.contributor.authorCherubini, A
dc.contributor.authorOnder, G
dc.contributor.authorCruz-Jentoft, A
dc.contributor.authorDenkinger, M
dc.contributor.authorvan der Cammen, T
dc.contributor.authorStevenson, J
dc.contributor.authorIbrahim, K
dc.contributor.authorRajkumar, C
dc.contributor.authorBakken, M
dc.contributor.authorBaeyens, JP
dc.contributor.authorCrome, P
dc.contributor.authorFrühwald, T
dc.contributor.authorGallaghar, P
dc.contributor.authorGuðmundsson, A
dc.contributor.authorKnol, W
dc.contributor.authorO’Mahony, D
dc.contributor.authorPilotto, A
dc.contributor.authorRönnemaa, E
dc.contributor.authorSerra-Rexach, JA
dc.contributor.authorSoulis, G
dc.contributor.authorvan Marum, R
dc.contributor.authorZiere, G
dc.contributor.authorMair, A
dc.contributor.authorBurkhardt, H
dc.contributor.authorNeumann-Podczaska, A
dc.contributor.authorWieczorowska-Tobis, K
dc.contributor.authorFernandes, MA
dc.contributor.authorGruner, H
dc.contributor.authorDallmeier, D
dc.contributor.authorBeuscart, J
dc.contributor.authorvan der Velde, N
dc.contributor.authorWehling, M
dc.date.accessioned2023-04-14T13:35:49Z
dc.date.available2023-04-14T13:35:49Z
dc.date.issued2020-01
dc.description.abstractBackground: Frailty and adverse drug effects are linked in the fact that polypharmacy is correlated with the severity of frailty; however, a causal relation has not been proven in older people with clinically manifest frailty. Methods: A literature search was performed in Medline to detect prospective randomized controlled trials (RCTs) testing the effects of pharmacological interventions or medication optimization in older frail adults on comprehensive frailty scores or partial aspects of frailty that were published from January 1998 to October 2019. Results: Twenty-five studies were identified, 4 on comprehensive frailty scores and 21 on aspects of frailty. Two trials on comprehensive frailty scores showed positive results on frailty although the contribution of medication review in a multidimensional approach was unclear. In the studies on aspects related to frailty, ten individual drug interventions showed improvement in physical performance, muscle strength or body composition utilizing alfacalcidol, teriparatide, piroxicam, testosterone, recombinant human chorionic gonadotropin, or capromorelin. There were no studies examining negative effects of drugs on frailty. Conclusion: So far, data on a causal relationship between drugs and frailty are inconclusive or related to single-drug interventions on partial aspects of frailty. There is a clear need for RCTs on this topic that should be based on a comprehensive, internationally consistent and thus reproducible concept of frailty assessment.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEur J Clin Pharmacol . 2021 Jan;77(1):1-12.pt_PT
dc.identifier.doi10.1007/s00228-020-02951-8pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/4495
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.subjectHCC MEDpt_PT
dc.subjectAgedpt_PT
dc.subjectHumanspt_PT
dc.subjectFrail Elderlypt_PT
dc.subjectFrailty / drug therapy*pt_PT
dc.subjectPolypharmacypt_PT
dc.subjectRandomized Controlled Trials as Topicpt_PT
dc.titleCurrent Evidence on the Impact of Medication Optimization or Pharmacological Interventions on Frailty or Aspects of Frailty: a Systematic Review of Randomized Controlled Trialspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage12pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleEuropean Journal of Clinical Pharmacologypt_PT
oaire.citation.volume77pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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