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Application of Hazard Functions to Investigate Recurrence After Curative-Intent Resection for Hepatocellular Carcinoma

2023-02Journal article Open access
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dc.contributor.authorLima, H
dc.contributor.authorAlaimo, L
dc.contributor.authorBrown, Z
dc.contributor.authorEndo, Y
dc.contributor.authorMoazzam, Z
dc.contributor.authorTsilimigras, D
dc.contributor.authorShaikh, C
dc.contributor.authorResende, V
dc.contributor.authorGuglielmi, A
dc.contributor.authorRatti, F
dc.contributor.authorAldrighetti, L
dc.contributor.authorPinto Marques, H
dc.contributor.authorSoubrane, O
dc.contributor.authorLam, V
dc.contributor.authorPoultsides, G
dc.contributor.authorPopescu, I
dc.contributor.authorAlexandrescu, S
dc.contributor.authorMartel, G
dc.contributor.authorHugh, T
dc.contributor.authorEndo, I
dc.contributor.authorShen, F
dc.contributor.authorPawlik, T
dc.date.accessioned2024-05-14T15:28:38Z
dc.date.available2024-05-14T15:28:38Z
dc.date.issued2023-02
dc.description.abstractBackground: Defining patterns and risk of recurrence can help inform surveillance strategies and patient counselling. We sought to characterize peak hazard rates (pHR) and peak time of recurrence among patients who underwent resection of hepatocellular carcinoma (HCC). Methods: 1434 patients who underwent curative-intent resection of HCC were identified from a multi-institutional database. Hazard, patterns, and peak rates of recurrence were characterized. Results: The overall hazard of recurrence peaked at 2.4 months (pHR: 0.0384), yet varied markedly. The incidence of recurrence increased with Barcelona Clinic Liver Cancer (BCLC) stage 0 (29%), A (54%), and B (64%). While the hazard function curve for BCLC 0 patients was relatively flat (pHR: <0.0177), BCLC A patients recurred with a peak at 2.4 months (pHR: 0.0365). Patients with BCLC B had a bimodal recurrence with a peak rate at 4.2 months (pHR: 0.0565) and another at 22.8 months. The incidence of recurrence also varied according to AFP level (≤400 ng/mL: 52.6% vs. >400 ng/mL: 36.3%) and Tumor Burden Score (low: 73.7% vs. medium: 50.6% vs. high: 24.2%) (both p < 0.001). Conclusion: Recurrence hazard rates for HCC varied substantially relative to both time and intensity/peak rates. TBS and AFP markedly impacted patterns of hazard risk of recurrence.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationHPB (Oxford) . 2023 Feb;25(2):260-268.pt_PT
dc.identifier.doi10.1016/j.hpb.2022.11.008pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/4899
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.subjectHCC CIRpt_PT
dc.subjectHumanspt_PT
dc.subjectCarcinoma, Hepatocellular* / surgerypt_PT
dc.subjectHepatectomypt_PT
dc.subjectLiver Neoplasms* / surgerypt_PT
dc.subjectNeoplasm Recurrence, Local / pathologypt_PT
dc.subjectNeoplasm Stagingpt_PT
dc.subjectRetrospective Studiespt_PT
dc.subjectalpha-Fetoproteinspt_PT
dc.titleApplication of Hazard Functions to Investigate Recurrence After Curative-Intent Resection for Hepatocellular Carcinomapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage268pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage260pt_PT
oaire.citation.titleHPBpt_PT
oaire.citation.volume25pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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