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Changes of Soluble CD40 Ligand in the Progression of Acute Myocardial Infarction Associate to Endothelial Nitric Oxide Synthase Polymorphisms and Vascular Endothelial Growth Factor But Not to Platelet CD62P Expression

2015-12Journal article Open access
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dc.contributor.authorNapoleão, P
dc.contributor.authorMonteiro, MC
dc.contributor.authorCabral, L
dc.contributor.authorCriado, MB
dc.contributor.authorRamos, C
dc.contributor.authorSelas, M
dc.contributor.authorViegas-Crespo, AM
dc.contributor.authorSaldanha, C
dc.contributor.authorMota Carmo, M
dc.contributor.authorCruz Ferreira, R
dc.contributor.authorPinheiro, T
dc.date.accessioned2016-06-07T15:39:58Z
dc.date.available2016-06-07T15:39:58Z
dc.date.issued2015-12
dc.description.abstractReported in vitro data implicated soluble CD40 ligand (sCD40L) in endothelial dysfunction and angiogenesis. However, whether sCD40L could exert that influence in endothelial dysfunction and angiogenesis after injury in acute myocardial infarction (AMI) patients remains unclear. In the present study, we evaluated the association of sCD40L with markers of platelet activation, endothelial, and vascular function during a recovery period early after AMI. To achieve this goal, the time changes of soluble, platelet-bound, and microparticle-bound CD40L levels over 1 month were assessed in AMI patients and correlated with endothelial nitric oxide synthase (eNOS) polymorphisms, vascular endothelial growth factor (VEGF) concentrations, and platelet expression of P-selectin (CD62P). The association of soluble form, platelet-bound, and microparticle-bound CD40L with CD62P expression on platelets, a marker of platelet activation, was also assessed to evaluate the role of CD40L in the thrombosis, whereas the association with eNOS and VEGF was to evaluate the role of CD40L in vascular dysfunction. This work shows for the first time that time changes of sCD40L over 1 month after myocardial infarct onset were associated with G894T eNOS polymorphism and with the VEGF concentrations, but not to the platelet CD62P expression. These results indicate that, in terms of AMI pathophysiology, the sCD40L cannot be consider just as being involved in thrombosis and inflammation but also as having a relevant role in vascular and endothelial dysfunction.pt_PT
dc.identifier.citationTransl Res. 2015 Dec;166(6):650-9pt_PT
dc.identifier.doi10.1016/j.trsl.2015.07.006pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/2512
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.subjectAgedpt_PT
dc.subjectBlood Platelets/metabolismpt_PT
dc.subjectDisease Progressionpt_PT
dc.subjectFemalept_PT
dc.subjectHumanspt_PT
dc.subjectMalept_PT
dc.subjectMiddle Agedpt_PT
dc.subjectMyocardial Infarction/enzymologypt_PT
dc.subjectNitric Oxide Synthase Type III/geneticspt_PT
dc.subjectP-Selectin/geneticspt_PT
dc.subjectRecombinant Fusion Proteins/bloodpt_PT
dc.subjectVascular Endothelial Growth Factor A/geneticspt_PT
dc.subjectPolymorphism, Geneticpt_PT
dc.subjectHSM CARpt_PT
dc.subjectMyocardial Infarction/metabolismpt_PT
dc.subjectMyocardial Infarction/pathologypt_PT
dc.titleChanges of Soluble CD40 Ligand in the Progression of Acute Myocardial Infarction Associate to Endothelial Nitric Oxide Synthase Polymorphisms and Vascular Endothelial Growth Factor But Not to Platelet CD62P Expressionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage659pt_PT
oaire.citation.issue6pt_PT
oaire.citation.startPage650pt_PT
oaire.citation.titleTranslational Research : the Journal of Laboratory and Clinical Medicinept_PT
oaire.citation.volume166pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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