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Liver Retransplantation in Patients With HIV-1 Infection: An International Multicenter Cohort Study

2016-02Journal article Open access
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dc.contributor.authorAgüero, F
dc.contributor.authorRimola, A
dc.contributor.authorStock, P
dc.contributor.authorGrossi, P
dc.contributor.authorRockstroh, JK
dc.contributor.authorAgarwal, K
dc.contributor.authorGarzoni, C
dc.contributor.authorBarcan, LA
dc.contributor.authorMaltez, F
dc.contributor.authorManzardo, C
dc.contributor.authorMari, M
dc.contributor.authorRagni, MV
dc.contributor.authorAnadol, E
dc.contributor.authorDi Benedetto, F
dc.contributor.authorNishida, S
dc.contributor.authorGastaca, M
dc.contributor.authorMiró, JM
dc.date.accessioned2017-07-21T10:14:41Z
dc.date.available2017-07-21T10:14:41Z
dc.date.issued2016-02
dc.description.abstractLiver retransplantation is performed in HIV-infected patients, although its outcome is not well known. In an international cohort study (eight countries), 37 (6%; 32 coinfected with hepatitis C virus [HCV] and five with hepatitis B virus [HBV]) of 600 HIV-infected patients who had undergone liver transplant were retransplanted. The main indications for retransplantation were vascular complications (35%), primary graft nonfunction (22%), rejection (19%), and HCV recurrence (13%). Overall, 19 patients (51%) died after retransplantation. Survival at 1, 3, and 5 years was 56%, 51%, and 51%, respectively. Among patients with HCV coinfection, HCV RNA replication status at retransplantation was the only significant prognostic factor. Patients with undetectable versus detectable HCV RNA had a survival probability of 80% versus 39% at 1 year and 80% versus 30% at 3 and 5 years (p = 0.025). Recurrence of hepatitis C was the main cause of death in the latter. Patients with HBV coinfection had survival of 80% at 1, 3, and 5 years after retransplantation. HIV infection was adequately controlled with antiretroviral therapy. In conclusion, liver retransplantation is an acceptable option for HIV-infected patients with HBV or HCV coinfection but undetectable HCV RNA. Retransplantation in patients with HCV replication should be reassessed prospectively in the era of new direct antiviral agents.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAm J Transplant. 2016 Feb;16(2):679-87pt_PT
dc.identifier.doi10.1111/ajt.13461pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/2731
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.subjectAdultpt_PT
dc.subjectCohort Studiespt_PT
dc.subjectCoinfectionpt_PT
dc.subjectFemalept_PT
dc.subjectFollow-Up Studiespt_PT
dc.subjectGraft Survivalpt_PT
dc.subjectHIV Infectionspt_PT
dc.subjectHIV-1pt_PT
dc.subjectHepaciviruspt_PT
dc.subjectHepatitis Bpt_PT
dc.subjectHepatitis B viruspt_PT
dc.subjectHepatitis Cpt_PT
dc.subjectHumanspt_PT
dc.subjectInternational Agenciespt_PT
dc.subjectMalept_PT
dc.subjectMiddle Agedpt_PT
dc.subjectPrognosispt_PT
dc.subjectReoperationpt_PT
dc.subjectRisk Factorspt_PT
dc.subjectSurvival Ratept_PT
dc.subjectLiver Transplantationpt_PT
dc.subjectPostoperative Complicationspt_PT
dc.subjectHCC INFpt_PT
dc.titleLiver Retransplantation in Patients With HIV-1 Infection: An International Multicenter Cohort Studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage687pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage679pt_PT
oaire.citation.titleAmerican Journal of Transplantationpt_PT
oaire.citation.volume16pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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