Publication
Bicuspid Aortic Valve Aortopathies: an Hemodynamics Characterization in Dilated Aortas
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Advisor(s)
Abstract(s)
Bicuspid aortic valve (BAV) aortopathy remains of difficult clinical management due to its heterogeneity and further assessment of related aortic hemodynamics is necessary. The aim of this study was to assess systolic hemodynamic indexes and wall stresses in patients with diverse BAV phenotypes and dilated ascending aortas. The aortic geometry was reconstructed from patient-specific images while the aortic valve was generated based on patient-specific measurements. Physiologic material properties and boundary conditions were applied and fully coupled fluid-structure interaction (FSI) analysis were conducted. Our dilated aortic models were characterized by the presence of abnormal hemodynamics with elevated degrees of flow skewness and eccentricity, regardless of BAV morphotype. Retrograde flow was also present. Both features, predicted by flow angle and flow reversal ratios, were consistently higher than those reported for non-dilated aortas. Right-handed helical flow was present, as well as elevated wall shear stress (WSS) on the outer ascending aortic wall. Our results suggest that the abnormal flow associated with BAV may play a role in aortic enlargement and progress it further on already dilated aortas.
Description
Keywords
Aorta Aortic Diseases Aortic Valve Case-Control Studies Dilatation, Pathologic Heart Valve Diseases Hemodynamics Humans Models, Cardiovascular Stress, Mechanical Systole HSM CAR
Citation
Comput Methods Biomech Biomed Engin. 2019 Jun;22(8):815-826.
Publisher
Taylor & Francis