Repository logo
 
Publication

Short and Long-Term Trajectories of the Post COVID-19 Condition: Results From the EuCARE POSTCOVID Study.

2025-04-29Text Open access
Simple item page
dc.contributor.authorSantoro, Andrea
dc.contributor.authorBai, Francesca
dc.contributor.authorGreco, Maria Francesca
dc.contributor.authorRovito, Roberta
dc.contributor.authorSala, Matteo
dc.contributor.authorBorghi, Lidia
dc.contributor.authorPiscopo, Kyrie
dc.contributor.authorVegni, Elena
dc.contributor.authorde Morais Caporali, Julia Fonseca
dc.contributor.authorMarinho, Carolina Coimbra
dc.contributor.authorLeite, Arnaldo Santos
dc.contributor.authorSantoro, Maria Mercedes
dc.contributor.authorSilberstein, Francesca Ceccherini
dc.contributor.authorIannetta, Marco
dc.contributor.authorJuozapaite, Dovile
dc.contributor.authorStrumiliene, Edita
dc.contributor.authorAlmeida, André
dc.contributor.authorToscano, Cristina
dc.contributor.authorQuinones, Jesus Arturo Ruiz
dc.contributor.authorCarioti, Luca
dc.contributor.authorMommo, Chiara
dc.contributor.authorFanti, Iuri
dc.contributor.authorIncardona, Francesca
dc.contributor.authorMarchetti, Giulia
dc.date.accessioned2025-08-28T14:03:26Z
dc.date.available2025-08-28T14:03:26Z
dc.date.issued2025-04-29
dc.description.abstractBackground: Post COVID-19 condition (PCC) affects 10-40% of patients and is characterized by persisting symptoms at ≥ 4 weeks after SARS-CoV-2 infection. Symptoms can last 7 or even more months. How long PCC persists and any changes in its clinical phenotypes over time require further investigation. We investigated PCC trajectories and factors associated with PCC persistence. Material and methods: We included both hospitalized COVID-19 patients and outpatients from February 2020 to June 2023, who underwent at least one follow-up visit after acute infection at San Paolo Hospital, University of Milan. Follow-up visits were conducted at the post COVID-19 clinic or via telemedicine. During each follow-up examination, patients completed a short version of the World Health Organization (WHO) Case Report Form (CRF) for ongoing symptoms, the Hospital Anxiety and Depression Scale (HADS), and a screening tool for Post-Traumatic Stress Disorder (PTSD). Statistical analyses involved Chi-square, Mann-Whitney, Kruskal-Wallis tests, and logistic regression analysis. Results: We enrolled 853 patients (median age 62, IQR 52-73; 41% females). 551/853 (64.6%), 152/418 (36.4%) and 21/69 (30.4%) presented PCC at median follow up of 3 (IQR 2-3), 7 (IQR 6-10) and 26 (IQR 20-33) months, respectively (p < 0.001). The main clinical phenotypes were fatigue, respiratory sequelae, brain fog and chronic pain; anosmia/dysgeusia was observed mostly in the first post-acute period. Female sex, acute disease in 2020, a longer hospital stay and no COVID-19 vaccination were associated with persistence or resolution of PCC compared to never having had PCC. Anxiety, depression and PTSD were more common in PCC patients. By fitting a logistic regression analysis, acute infection in 2020 remained independently associated with persistent PCC, adjusting for age, sex, preexisting comorbidities and disease severity (AOR 0.479 for 2021 vs 2020, 95%CI 0.253-0.908, p = 0.024; AOR 0.771 for 2022 vs 2020, 95%CI 0.259-2.297, p = 0.641; AOR 0.086 for 2023 vs 2020, 95%CI 0.086-3.830, p = 0.565). Conclusions: There was a reduction in the PCC burden 7 months following the acute phase; still, one third of patients experienced long-lasting symptoms. The main clinical presentations of PCC remain fatigue, respiratory symptoms, brain fog, and chronic pain. Having had SARS-CoV-2 infection during the first pandemic phases appears to be associated with persistent PCC.eng
dc.identifier.citationBMC Infect Dis . 2025 Apr 29;25(1):625. doi: 10.1186/s12879-025-10805-w.
dc.identifier.doi10.1186/s12879-025-10805-w.
dc.identifier.pmid40301791
dc.identifier.urihttp://hdl.handle.net/10400.17/5158
dc.language.isoeng
dc.peerreviewedyes
dc.publisherBioMed Central
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectHSM MED
dc.subjectAged
dc.subjectFemale
dc.subjectMale
dc.subjectHumans
dc.subjectAnxiety / epidemiology
dc.subjectMiddle Aged
dc.subjectCOVID-19* / complications
dc.subjectCOVID-19* / epidemiology
dc.subjectCOVID-19* / psychology
dc.subjectFatigue
dc.subjectDepression / epidemiology
dc.subjectPost-Acute COVID-19 Syndrome
dc.subjectSARS-CoV-2
dc.subjectStress Disorders
dc.subjectPost-Traumatic / epidemiology
dc.titleShort and Long-Term Trajectories of the Post COVID-19 Condition: Results From the EuCARE POSTCOVID Study.eng
dc.typetext
dspace.entity.typePublication
oaire.citation.issue1
oaire.citation.startPage625
oaire.citation.titleBMC Infectious Diseases
oaire.citation.volume25
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
BMC Infect Dis.pdf
Size:
827.71 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
4.03 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

MED - Artigos