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Preoperative Risk Score (PreopScore) to Predict Overall Survival After Resection for Hepatocellular Carcinoma.

2023-03Text Open access
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dc.contributor.authorEndo, Yutaka
dc.contributor.authorLima, Henrique A
dc.contributor.authorAlaimo, Laura
dc.contributor.authorMoazzam, Zorays
dc.contributor.authorBrown, Zachary
dc.contributor.authorShaikh, Chanza F
dc.contributor.authorRatti, Francesca
dc.contributor.authorPinto Marques, Hugo
dc.contributor.authorSoubrane, Olivier
dc.contributor.authorLam, Vincent
dc.contributor.authorPoultsides, George A
dc.contributor.authorPopescu, Irinel
dc.contributor.authorAlexandrescu, Sorin
dc.contributor.authorMartel, Guillaume
dc.contributor.authorWorkneh, Aklile
dc.contributor.authorGuglielmi, Alfredo
dc.contributor.authorHugh, Tom
dc.contributor.authorAldrighetti, Luca
dc.contributor.authorShen, Feng
dc.contributor.authorEndo, Itaru
dc.contributor.authorPawlik, Timothy M
dc.contributor.editorElsevier
dc.date.accessioned2025-04-15T15:06:44Z
dc.date.available2025-04-15T15:06:44Z
dc.date.issued2023-03
dc.description.abstractBackground: This study aimed to develop a holistic risk score incorporating preoperative tumor, liver, nutritional, and inflammatory markers to predict overall survival (OS) after hepatectomy for hepatocellular carcinoma (HCC). Methods: Patients who underwent curative-intent surgery for HCC between 2000 and 2020 were identified using an international multi-institutional database. Preoperative predictors associated with OS were selected and a prognostic risk score model (PreopScore) was developed and validated using cross-validation. Results: A total of 1676 patients were included. On multivariable analysis, preoperative parameters associated with OS included α-feto protein (hazard ratio [HR]1.17, 95%CI 1.03-1.34), neutrophil-to-lymphocyte ratio (HR2.62, 95%CI 1.30-5.30), albumin (HR0.49, 95%CI 0.34-0.70), gamma-glutamyl transpeptidase (HR1.00, 95%CI 1.00-1.00), as well as vascular involvement (HR3.52, 95%CI 2.10-5.89) and tumor burden score (medium, HR3.49, 95%CI 1.62-7.58; high, HR3.21, 95%CI 1.40-7.35) on preoperative imaging. A weighted PreopScore was devised and made available online (https://yutaka-endo.shinyapps.io/PrepoScore_Shiny/). Patients with a PreopScore 0-2, 2-3.5, and >3.5 had incrementally worse 5-year OS of 85.8%, 70.7%, and 52.4%, respectively (p < 0.001). The c-index of the test and validation cohort were 0.75 and 0.71, respectively. The PreopScore outperformed individual parameters and previous HCC staging systems. Discussion: The PreopScore can be used as a better guide to preoperatively identify patients and individualize pre-/post-operative strategies.eng
dc.identifier.citationHPB (Oxford) . 2023 Mar;25(3):353-362.
dc.identifier.doi10.1016/j.hpb.2022.12.009
dc.identifier.pmid36670007
dc.identifier.urihttp://hdl.handle.net/10400.17/5069
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectHCC CIR
dc.subjectHumans
dc.subjectPrognosis
dc.subjectCarcinoma
dc.subjectHepatocellular* / surgery
dc.subjectHepatectomy
dc.subjectLiver Neoplasms* / surgery
dc.subjectRetrospective Studies
dc.titlePreoperative Risk Score (PreopScore) to Predict Overall Survival After Resection for Hepatocellular Carcinoma.eng
dc.typetext
dspace.entity.typePublication
oaire.citation.endPage362
oaire.citation.issue3
oaire.citation.startPage353
oaire.citation.titleHPB
oaire.citation.volume25
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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