Short and Extended Provocation Tests Have Similar Negative Predictive Value in Non-Immediate Hypersensitivity to Beta-Lactams in Children

Regateiro, FS; Rezende, I; Pinto, N; Abreu, C; Carreiro-Martins, P; Gomes, ER

http://hdl.handle.net/10400.17/3439

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Abstract(s)

Drug provocation tests (DPTs) are the gold-standard method to diagnose non-immediate hypersensitivity reactions (NIHSR) to beta-lactam antibiotics (BL) in children. Our aim was to compare the negative predictive value (NPV) of one-day (short) DPT versus 3-7 days (extended) DPT for the diagnosis of NIHSR to BL in paediatric age. A secondary aim was to compare confidence on drug re-exposure after short and extended negative DPTs.

Keywords

Allergens Anti-Bacterial Agents Bronchial Provocation Tests Child Child, Preschool Drug Hypersensitivity Drug Substitution Female Humans Hypersensitivity, Delayed Male Predictive Value of Tests Prognosis Skin Tests beta-Lactams HDE ALER