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Signal Intensity Change on Unenhanced T1-Weighted Images in Dentate Nucleus Following Gadobenate Dimeglumine in Patients With and Without Previous Multiple Administrations of Gadodiamide

2016-11Journal article Open access
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dc.contributor.authorRamalho, J
dc.contributor.authorSemelka, RC
dc.contributor.authorAlObaidy, M
dc.contributor.authorRamalho, M
dc.contributor.authorNunes, RH
dc.contributor.authorCastillo, M
dc.date.accessioned2018-03-15T15:34:26Z
dc.date.available2018-03-15T15:34:26Z
dc.date.issued2016-11
dc.description.abstractOBJECTIVES: To evaluate the impact of previous administration of gadodiamide and neural tissue gadolinium deposition in patients who received gadobenate dimeglumine. METHODS: Our population included 62 patients who underwent at least three administrations of gadobenate dimeglumine, plus an additional contrast-enhanced last MRI for reference, divided into two groups: group 1, patients who in addition to gadobenate dimeglumine administrations had prior exposure to multiple doses of gadodiamide; group 2, patients without previous exposure to other gadolinium-based contrast agent (GBCAs). Quantitative analysis was performed on the first and last gadobenate dimeglumine MRIs in both groups. Dentate nucleus-to-middle cerebellar peduncle signal intensity ratios (DN/MCP) and relative change (RC) in signal over time were calculated and compared between groups using generalized additive model. RESULTS: Group 1 showed significant increase in baseline and follow-up DN/MCP compared to group 2 (p < 0.0001). The RC DN/MCP showed a non-statistically significant trend towards an increase in patients who underwent previous gadodiamide (p = 0.0735). CONCLUSION: There is increased T1 signal change over time in patients who underwent gadobenate dimeglumine and had received prior gadodiamide compared to those without known exposure to previous gadodiamide. A potentiating effect from prior gadodiamide on subsequent administered gadobenate dimeglumine may occur. KEY POINTS: • Neural gadolinium deposition is associated with multiple administrations of less stable GBCAs. • Less stable GBCA effect on subsequent more stable GBCA administrations is undetermined. • Significant increase of DN/MCP was seen in patients with previous gadodiamide exposure. • RC DN/MCP showed a non-significant increase in patients who received previous gadodiamide. • Potentiating effects from prior gadodiamide on subsequent administered gadobenate dimeglumine may occur.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEur Radiol. 2016 Nov;26(11):4080-4088pt_PT
dc.identifier.doi10.1007/s00330-016-4269-7pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/2953
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Verlagpt_PT
dc.subjectAdultpt_PT
dc.subjectAgedpt_PT
dc.subjectAged, 80 and overpt_PT
dc.subjectCerebellar Nucleipt_PT
dc.subjectCerebellumpt_PT
dc.subjectContrast Mediapt_PT
dc.subjectFemalept_PT
dc.subjectGadoliniumpt_PT
dc.subjectGadolinium DTPApt_PT
dc.subjectHumanspt_PT
dc.subjectLongitudinal Studiespt_PT
dc.subjectMagnetic Resonance Imagingpt_PT
dc.subjectMalept_PT
dc.subjectMegluminept_PT
dc.subjectMiddle Agedpt_PT
dc.subjectOrganometallic Compoundspt_PT
dc.subjectCHLC IMApt_PT
dc.titleSignal Intensity Change on Unenhanced T1-Weighted Images in Dentate Nucleus Following Gadobenate Dimeglumine in Patients With and Without Previous Multiple Administrations of Gadodiamidept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage4088pt_PT
oaire.citation.issue11pt_PT
oaire.citation.startPage4080pt_PT
oaire.citation.titleEuropean Radiologypt_PT
oaire.citation.volume26pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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