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Long-Term Evaluation of Endothelial Function in Kawasaki Disease Patients

2013-08Journal article Open access
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dc.contributor.authorPinto, MF
dc.contributor.authorLaranjo, S
dc.contributor.authorParamés, F
dc.contributor.authorFreitas, I
dc.contributor.authorMota-Carmo, M
dc.date.accessioned2017-12-11T16:12:04Z
dc.date.available2017-12-11T16:12:04Z
dc.date.issued2013-08
dc.description.abstractBACKGROUND: Kawasaki disease is an acute systemic vasculitis. Cardiac complications are frequent and include endothelial dysfunction in patients with coronary anomalies. So far, the presence of endothelial dysfunction in patients with no coronary lesions has not been demonstrated. Peripheral arterial tonometry (Endo-PAT) measures the microvascular function in response to local ischaemia and has been validated in adult population, but its use in children is scarce. Aim To evaluate endothelial dysfunction in children as a long-term complication after Kawasaki disease using Endo-PAT. METHODS: We evaluated two groups of subjects: (1) Kawasaki disease patients over 11 years of age, diagnosed for >5 years, with no coronary lesions, or any other risk factors for cardiovascular disease; (2) control group of individuals without cardiovascular risk factors. Patients and controls were clinically accessed. Endo-PAT was performed to determine reactive hyperaemia index and augmentation index. RESULTS: A total of 35 individuals (21 males, age 21 ± 6 years) were evaluated (group 1: 19; controls: 16). Kawasaki disease patients presented significant lower reactive hyperaemia index (1.68 ± 0.49 versus 2.31 ± 0.53; p = 0.001). Augmentation index was similar in both groups (-10 ± 7 versus -11 ± 5; p > 0.005). Most patients with Kawasaki disease disclosed endothelial dysfunction (68%) compared with only 12% in controls. CONCLUSIONS: Endo-PAT is feasible and reproducible in the child population. Endothelial dysfunction is a frequent long-term complication in patients after Kawasaki disease with normal appearing coronary arteries. However, these results need validation in a larger population.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCardiol Young. 2013 Aug;23(4):517-22pt_PT
dc.identifier.doi10.1017/S1047951112001357pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/2819
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherCambridge University Presspt_PT
dc.subjectAdolescentpt_PT
dc.subjectAdultpt_PT
dc.subjectCase-Control Studiespt_PT
dc.subjectEndothelium, Vascularpt_PT
dc.subjectFemalept_PT
dc.subjectHumanspt_PT
dc.subjectHyperemiapt_PT
dc.subjectMalept_PT
dc.subjectManometrypt_PT
dc.subjectMicrovesselspt_PT
dc.subjectMucocutaneous Lymph Node Syndromept_PT
dc.subjectPulse Wave Analysispt_PT
dc.subjectYoung Adultpt_PT
dc.subjectHSM CAR PEDpt_PT
dc.subjectHSM CARpt_PT
dc.titleLong-Term Evaluation of Endothelial Function in Kawasaki Disease Patientspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage522pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage517pt_PT
oaire.citation.titleCardiology in the Youngpt_PT
oaire.citation.volume23pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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