Publication
Late Onset Neuromyelitis Optica Spectrum Disorders (LONMOSD) from a Nationwide Portuguese Study: Anti-AQP4 Positive, Anti-MOG Positive and Seronegative Subgroups
dc.contributor.author | Santos, E | |
dc.contributor.author | Moura, J | |
dc.contributor.author | Samões, R | |
dc.contributor.author | Sousa, AP | |
dc.contributor.author | Mendonça, T | |
dc.contributor.author | Abreu, P | |
dc.contributor.author | Guimarães, J | |
dc.contributor.author | Correia, I | |
dc.contributor.author | Durães, J | |
dc.contributor.author | Sousa, L | |
dc.contributor.author | Ferreira, J | |
dc.contributor.author | de Sá, J | |
dc.contributor.author | Sousa, F | |
dc.contributor.author | Sequeira, M | |
dc.contributor.author | Correia, AS | |
dc.contributor.author | André, AL | |
dc.contributor.author | Basílio, C | |
dc.contributor.author | Arenga, M | |
dc.contributor.author | Brás Marques, I | |
dc.contributor.author | Perdigão, S | |
dc.contributor.author | Alves, I | |
dc.contributor.author | Santos, M | |
dc.contributor.author | Salgado, V | |
dc.contributor.author | Palos, A | |
dc.contributor.author | Guerreiro, R | |
dc.contributor.author | Isidoro, L | |
dc.contributor.author | Boleixa, D | |
dc.contributor.author | Carneiro, P | |
dc.contributor.author | Neves, E | |
dc.contributor.author | Martins Silva, A | |
dc.contributor.author | Gonçalves, G | |
dc.contributor.author | Sá, MJ | |
dc.date.accessioned | 2023-02-20T15:13:32Z | |
dc.date.available | 2023-02-20T15:13:32Z | |
dc.date.issued | 2022 | |
dc.description.abstract | Introduction: Several neuroimmunological disorders have distinct phenotypes according to the age of onset, as in multiple sclerosis or myasthenia gravis. It is also described that late onset NMOSD (LONMOSD) has a different phenotype. Objective: To describe the clinical/demographic characteristics of the LONMOSD and distinguish them from those with early onset (EONMOSD). Methods: From a nationwide Portuguese NMOSD study we analyzed the clinical/demographic characteristics of the LONMOSD. Results: From the 180 Portuguese patients 45 had disease onset after 50 years old, 80% were female. 23 had anti-AQP4 antibodies (51.1%), 13 anti-MOG antibodies (28.9%) and 9 were double seronegative (20.0%). The most common presenting phenotypes in LONMOSD were transverse myelitis (53.3%) and optic neuritis (26.7%), without difference from EONMOSD (p = 0.074). The mean EDSS for LONMOSD was 6.0 (SD=2.8), after a mean follow-up time of 4.58 (SD=4.47) years, which was significantly greater than the mean EDSS of EONMOSD (3.25, SD=1.80)(p = 0.022). Anti-AQP4 antibodies positive LONMOSD patients had increased disability compared to anti-MOG antibodies positive LONMOSD (p = 0.022). The survival analysis showed a reduced time to use a cane for LONMOSD, irrespective of serostatus (p<0.001). Conclusions: LONMOSD has increased disability and faster progression, despite no differences in the presenting clinical phenotype were seen in our cohort. | pt_PT |
dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
dc.identifier.citation | Mult Scler Relat Disord . 2022 Jul;63:103845. | pt_PT |
dc.identifier.doi | 10.1016/j.msard.2022.103845 | pt_PT |
dc.identifier.uri | http://hdl.handle.net/10400.17/4413 | |
dc.language.iso | eng | pt_PT |
dc.peerreviewed | yes | pt_PT |
dc.publisher | Elsevier | pt_PT |
dc.subject | CHLC NEU | pt_PT |
dc.subject | Aquaporin 4 | pt_PT |
dc.subject | Humans | pt_PT |
dc.subject | Male | pt_PT |
dc.subject | Female | pt_PT |
dc.subject | Autoantibodies | pt_PT |
dc.subject | Myelitis, Transverse* | pt_PT |
dc.subject | Neuromyelitis Optica* / epidemiology | pt_PT |
dc.subject | Portugal / epidemiology | pt_PT |
dc.title | Late Onset Neuromyelitis Optica Spectrum Disorders (LONMOSD) from a Nationwide Portuguese Study: Anti-AQP4 Positive, Anti-MOG Positive and Seronegative Subgroups | pt_PT |
dc.type | journal article | |
dspace.entity.type | Publication | |
oaire.citation.startPage | 103845 | pt_PT |
oaire.citation.title | Multiple Sclerosis and Related Disorders | pt_PT |
oaire.citation.volume | 63 | pt_PT |
rcaap.rights | openAccess | pt_PT |
rcaap.type | article | pt_PT |