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Late Onset Neuromyelitis Optica Spectrum Disorders (LONMOSD) from a Nationwide Portuguese Study: Anti-AQP4 Positive, Anti-MOG Positive and Seronegative Subgroups

dc.contributor.authorSantos, E
dc.contributor.authorMoura, J
dc.contributor.authorSamões, R
dc.contributor.authorSousa, AP
dc.contributor.authorMendonça, T
dc.contributor.authorAbreu, P
dc.contributor.authorGuimarães, J
dc.contributor.authorCorreia, I
dc.contributor.authorDurães, J
dc.contributor.authorSousa, L
dc.contributor.authorFerreira, J
dc.contributor.authorde Sá, J
dc.contributor.authorSousa, F
dc.contributor.authorSequeira, M
dc.contributor.authorCorreia, AS
dc.contributor.authorAndré, AL
dc.contributor.authorBasílio, C
dc.contributor.authorArenga, M
dc.contributor.authorBrás Marques, I
dc.contributor.authorPerdigão, S
dc.contributor.authorAlves, I
dc.contributor.authorSantos, M
dc.contributor.authorSalgado, V
dc.contributor.authorPalos, A
dc.contributor.authorGuerreiro, R
dc.contributor.authorIsidoro, L
dc.contributor.authorBoleixa, D
dc.contributor.authorCarneiro, P
dc.contributor.authorNeves, E
dc.contributor.authorMartins Silva, A
dc.contributor.authorGonçalves, G
dc.contributor.authorSá, MJ
dc.date.accessioned2023-02-20T15:13:32Z
dc.date.available2023-02-20T15:13:32Z
dc.date.issued2022
dc.description.abstractIntroduction: Several neuroimmunological disorders have distinct phenotypes according to the age of onset, as in multiple sclerosis or myasthenia gravis. It is also described that late onset NMOSD (LONMOSD) has a different phenotype. Objective: To describe the clinical/demographic characteristics of the LONMOSD and distinguish them from those with early onset (EONMOSD). Methods: From a nationwide Portuguese NMOSD study we analyzed the clinical/demographic characteristics of the LONMOSD. Results: From the 180 Portuguese patients 45 had disease onset after 50 years old, 80% were female. 23 had anti-AQP4 antibodies (51.1%), 13 anti-MOG antibodies (28.9%) and 9 were double seronegative (20.0%). The most common presenting phenotypes in LONMOSD were transverse myelitis (53.3%) and optic neuritis (26.7%), without difference from EONMOSD (p = 0.074). The mean EDSS for LONMOSD was 6.0 (SD=2.8), after a mean follow-up time of 4.58 (SD=4.47) years, which was significantly greater than the mean EDSS of EONMOSD (3.25, SD=1.80)(p = 0.022). Anti-AQP4 antibodies positive LONMOSD patients had increased disability compared to anti-MOG antibodies positive LONMOSD (p = 0.022). The survival analysis showed a reduced time to use a cane for LONMOSD, irrespective of serostatus (p<0.001). Conclusions: LONMOSD has increased disability and faster progression, despite no differences in the presenting clinical phenotype were seen in our cohort.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMult Scler Relat Disord . 2022 Jul;63:103845.pt_PT
dc.identifier.doi10.1016/j.msard.2022.103845pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/4413
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.subjectCHLC NEUpt_PT
dc.subjectAquaporin 4pt_PT
dc.subjectHumanspt_PT
dc.subjectMalept_PT
dc.subjectFemalept_PT
dc.subjectAutoantibodiespt_PT
dc.subjectMyelitis, Transverse*pt_PT
dc.subjectNeuromyelitis Optica* / epidemiologypt_PT
dc.subjectPortugal / epidemiologypt_PT
dc.titleLate Onset Neuromyelitis Optica Spectrum Disorders (LONMOSD) from a Nationwide Portuguese Study: Anti-AQP4 Positive, Anti-MOG Positive and Seronegative Subgroupspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage103845pt_PT
oaire.citation.titleMultiple Sclerosis and Related Disorderspt_PT
oaire.citation.volume63pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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