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Biochemical and Anthropometric Outcomes in Paediatric Patients with Heterozygous Familial Hypercholesterolemia after COVID-19 Pandemic Lockdowns: An Exploratory Analysis

2024-07Journal article Open access
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dc.contributor.authorPeres, M
dc.contributor.authorMoreira-Rosário, A
dc.contributor.authorPadeira, G
dc.contributor.authorGaspar Silva, P
dc.contributor.authorCorreia, C
dc.contributor.authorNunes, A
dc.contributor.authorGarcia, E
dc.contributor.authorFaria, A
dc.contributor.authorTeixeira, D
dc.contributor.authorCalhau, C
dc.contributor.authorPereira-da-Silva, L
dc.contributor.authorFerreira, AC
dc.contributor.authorCésar Rocha, J
dc.date.accessioned2024-07-30T15:56:50Z
dc.date.available2024-07-30T15:56:50Z
dc.date.issued2024-07
dc.description.abstractThe COVID-19 pandemic lockdowns affected the lifestyles of children and adolescents, leading to an increase in childhood obesity. Paediatric patients with familial hypercholesterolemia (FH) may be more susceptible to lockdown effects due to their increased cardiovascular risk. However, data are lacking. We investigated the effect of lockdowns on the metabolic profile of paediatric patients with FH. Blood lipids and anthropometry measured in September 2021-April 2022 were retrospectively compared with pre-pandemic values. Thirty participants were included (1-16 years; 57% female). From baseline to post-pandemic, median [P25, P75] blood LDL-C concentration was 125 [112, 150] mg/dL vs. 125 [100, 147] mg/dL (p = 0.894); HDL-C was 58 [52, 65] mg/dL vs. 56 [51, 61] mg/dL (p = 0.107); triglycerides were 64 [44, 86] mg/dL vs. 59 [42, 86] mg/dL (p = 0.178). The BMI z-score did not change significantly (0.19 [-0.58, 0.89] vs. 0.30 [-0.48, 1.10], p = 0.524). The lack of deterioration in metabolic profiles during lockdowns is positive, as some deterioration was expected. We speculate that patients and caregivers were successfully educated about healthy lifestyle and dietary habits. Our results should be interpreted with caution since the study sample was small and heterogeneous. Multicentre research is needed to better understand the impact of lockdowns on this population.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationNutrients . 2024 Jul 8;16(13):2170.pt_PT
dc.identifier.doi10.3390/nu16132170pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/4967
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.subjectHCC MTBpt_PT
dc.subjectAdolescentpt_PT
dc.subjectAnthropometrypt_PT
dc.subjectBody Mass Indexpt_PT
dc.subjectChildpt_PT
dc.subjectCOVID-19* / epidemiologypt_PT
dc.subjectCOVID-19* / prevention & controlpt_PT
dc.subjectChild, Preschoolpt_PT
dc.subjectCholesterol, HDL / bloodpt_PT
dc.subjectCholesterol, LDL / bloodpt_PT
dc.subjectFemalept_PT
dc.subjectHumanspt_PT
dc.subjectInfantpt_PT
dc.subjectHyperlipoproteinemia Type II* / bloodpt_PT
dc.subjectLipids / bloodpt_PT
dc.subjectMalept_PT
dc.subjectPandemicspt_PT
dc.subjectQuarantinept_PT
dc.subjectPediatric Obesity / epidemiologypt_PT
dc.subjectRetrospective Studiespt_PT
dc.subjectSARS-CoV-2*pt_PT
dc.subjectTriglycerides / bloodpt_PT
dc.titleBiochemical and Anthropometric Outcomes in Paediatric Patients with Heterozygous Familial Hypercholesterolemia after COVID-19 Pandemic Lockdowns: An Exploratory Analysispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue13pt_PT
oaire.citation.startPage2170pt_PT
oaire.citation.titleNutrientspt_PT
oaire.citation.volume16pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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