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Clinical and Bacteriological Survey of Diabetic Foot Infections in Lisbon

2012Journal article Open access
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dc.contributor.authorMendes, JJ
dc.contributor.authorMarques-Costa, A
dc.contributor.authorVilela, C
dc.contributor.authorNeves, J
dc.contributor.authorCandeias, N
dc.contributor.authorCavaco-Silva, P
dc.contributor.authorMelo-Cristino, J
dc.date.accessioned2012-11-08T15:52:30Z
dc.date.available2012-11-08T15:52:30Z
dc.date.issued2012
dc.description.abstractAIMS: An epidemiological survey of diabetic foot infections (DFIs) in Lisbon, stratifying the bacterial profile based on patient demographical data, diabetic foot characteristics (PEDIS classification), ulcer duration and antibiotic therapy. METHODS: A transversal observational multicenter study, with clinical data collection using a structured questionnaire and microbiological products (aspirates, biopsies or swabs collected using the Levine method) of clinically infected foot ulcers of patients with diabetes mellitus (DM). RESULTS: Forty-nine hospitalized and ambulatory patients were enrolled in this study, and 147 microbial isolates were cultured. Staphylococcus was the main genus identified, and methicillin-resistant Staphylococcus aureus (MRSA) was present in 24.5% of total cases. In the clinical samples collected from patients undergoing antibiotic therapy, 93% of the antibiotic regimens were considered inadequate based on the antibiotic susceptibility test results. The average duration of an ulcer with any isolated multi-drug resistant (MDR) organism was 29 days, and previous treatment with fluoroquinolones was statistically associated with multi-drug resistance. CONCLUSIONS: Staphylococcus aureus was the most common cause of DFIs in our area. Prevalence and precocity of MDR organisms, namely MRSA, were high and were probably related to previous indiscriminate antibiotic use. Clinicians should avoid fluoroquinolones and more frequently consider the use of empirical anti-MRSA therapy.por
dc.identifier.citationDiabetes Res Clin Pract. 2012 Jan;95(1):153-61por
dc.identifier.urihttp://hdl.handle.net/10400.17/728
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevierpor
dc.subjectAnti-Bacterial Agents/therapeutic usepor
dc.subjectDiabetic Foot/epidemiologypor
dc.subjectDiabetic Foot/microbiologypor
dc.subjectPortugalpor
dc.subjectFluoroquinolones/therapeutic usepor
dc.subjectStaphylococcal Skin Infections/drug therapypor
dc.subjectHSM
dc.subjectHSAC
dc.subjectHCC
dc.subjectPrevalence
dc.subjectStaphylococcal Skin Infections/epidemiology
dc.subjectStaphylococcal Skin Infections/microbiology
dc.subjectStaphylococcus aureus/isolation & purification
dc.titleClinical and Bacteriological Survey of Diabetic Foot Infections in Lisbonpor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage161por
oaire.citation.startPage153por
oaire.citation.titleDiabetes Research and Clinical Practicepor
rcaap.rightsopenAccesspor
rcaap.typearticlepor

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