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Customized Human Milk Fortification Based on Measured Human Milk Composition to Improve the Quality of Growth in Very Preterm Infants: A Mixed-Cohort Study Protocol

2021Journal article Open access
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dc.contributor.authorCardoso, M
dc.contributor.authorVirella, D
dc.contributor.authorMacedo, I
dc.contributor.authorSilva, D
dc.contributor.authorPereira-da-Silva, L
dc.date.accessioned2021-06-24T09:29:31Z
dc.date.available2021-06-24T09:29:31Z
dc.date.issued2021
dc.description.abstractAdequate nutrition of very preterm infants comprises fortification of human milk (HM), which helps to improve their nutrition and health. Standard HM fortification involves a fixed dose of a multi-nutrient HM fortifier, regardless of the composition of HM. This fortification method requires regular measurements of HM composition and has been suggested to be a more accurate fortification method. This observational study protocol is designed to assess whether the target HM fortification method (contemporary cohort) improves the energy and macronutrient intakes and the quality of growth of very preterm infants, compared with the previously used standard HM fortification (historical cohorts). In the contemporary cohort, a HM multi-nutrient fortifier and modular supplements of protein and fat are used for HM fortification, and the enteral nutrition recommendations of the European Society for Paediatric Gastroenterology Hepatology and Nutrition for preterm infants will be considered. For both cohorts, the composition of HM is assessed using the Miris Human Milk analyzer (Uppsala, Sweden). The quality of growth will be assessed by in-hospital weight, length, and head circumference growth velocities and a single measurement of adiposity (fat mass percentage and fat mass index) performed just after discharge, using the air displacement plethysmography method (Pea Pod, Cosmed, Italy). ClinicalTrials.gov registration number: NCT04400396.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationInt J Environ Res Public Health. 2021;18(2):823pt_PT
dc.identifier.doi10.3390/ijerph18020823pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/3753
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPI - Multidisciplinary Digital Publishing Institutept_PT
dc.subjectChildpt_PT
dc.subjectCohort Studiespt_PT
dc.subjectFood, Fortifiedpt_PT
dc.subjectHumanspt_PT
dc.subjectInfantpt_PT
dc.subjectInfant, Newbornpt_PT
dc.subjectItalypt_PT
dc.subjectObservational Studies as Topicpt_PT
dc.subjectSwedenpt_PT
dc.subjectInfant, Prematurept_PT
dc.subjectMilk, Humanpt_PT
dc.subjectMAC DIEpt_PT
dc.subjectHDE UCI NEOpt_PT
dc.titleCustomized Human Milk Fortification Based on Measured Human Milk Composition to Improve the Quality of Growth in Very Preterm Infants: A Mixed-Cohort Study Protocolpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue2pt_PT
oaire.citation.startPage823pt_PT
oaire.citation.titleInternational journal of environmental research and public healthpt_PT
oaire.citation.volume18pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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