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Classification of Intrahepatic Cholangiocarcinoma into Perihilar Versus Peripheral Subtype

2024Journal article Open access
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dc.contributor.authorWei, T
dc.contributor.authorLu, J
dc.contributor.authorXiao, XL
dc.contributor.authorWeiss, M
dc.contributor.authorPopescu, I
dc.contributor.authorPinto Marques, H
dc.contributor.authorAldrighetti, L
dc.contributor.authorMaithel, SK
dc.contributor.authorPulitano, C
dc.contributor.authorBauer, TW
dc.contributor.authorShen, F
dc.contributor.authorPoultsides, GA
dc.contributor.authorSoubrane, O
dc.contributor.authorMartel, G
dc.contributor.authorKoerkamp, BG
dc.contributor.authorItaru, E
dc.contributor.authorLv, Y
dc.contributor.authorZhang, XF
dc.contributor.authorPawlik, TM
dc.date.accessioned2024-08-13T09:46:02Z
dc.date.available2024-08-13T09:46:02Z
dc.date.issued2024
dc.description.abstractBackground: Intrahepatic cholangiocarcinoma (ICC) constitutes a group of heterogeneous malignancies within the liver. We sought to subtype ICC based on anatomical origin of tumors, as well as propose modifications of the current classification system. Methods: Patients undergoing curative-intent resection for ICC, hilar cholangiocarcinoma (CCA), or hepatocellular carcinoma (HCC) were identified from three international multi-institutional consortia of databases. Clinicopathological characteristics and survival outcomes were assessed. Results: Among 1264 patients with ICC, 1066 (84.3%) were classified as ICC-peripheral subtype, whereas 198 (15.7%) were categorized as ICC-perihilar subtype. Compared with ICC-peripheral subtype, ICC-perihilar subtype was more often associated with aggressive tumor characteristics, including a higher incidence of nodal metastasis, macro- and microvascular invasion, perineural invasion, as well as worse overall survival (OS) (median: ICC-perihilar 19.8 vs. ICC-peripheral 37.1 months; p < 0.001) and disease-free survival (DFS) (median: ICC-perihilar 12.8 vs. ICC-peripheral 15.2 months; p = 0.019). ICC-perihilar subtype and hilar CCA had comparable OS (19.8 vs. 21.4 months; p = 0.581) and DFS (12.8 vs. 16.8 months; p = 0.140). ICC-peripheral subtype tumors were associated with more advanced tumor features, as well as worse survival outcomes versus HCC (OS, median: ICC-peripheral 37.1 vs. HCC 74.3 months; p < 0.001; DFS, median: ICC-peripheral 15.2 vs. HCC 45.5 months; p < 0.001). Conclusions: ICC should be classified as ICC-perihilar and ICC-peripheral subtype based on distinct clinicopathological features and survival outcomes. ICC-perihilar subtype behaved more like carcinoma of the bile duct (i.e., hilar CCA), whereas ICC-peripheral subtype had features and a prognosis more akin to a primary liver malignancy.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAnn Surg Oncol . 2024 Feb;31(2):1232-1242pt_PT
dc.identifier.doi10.1245/s10434-023-14502-3pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/4983
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerlinkpt_PT
dc.subjectBile Duct Neoplasms* / pathologypt_PT
dc.subjectBile Ducts, Intrahepatic / pathologypt_PT
dc.subjectCarcinoma, Hepatocellular* / surgerypt_PT
dc.subjectCholangiocarcinoma* / pathologypt_PT
dc.subjectHumanspt_PT
dc.subjectLiver Neoplasms* / pathologypt_PT
dc.subjectPrognosispt_PT
dc.subjectHCC CIRpt_PT
dc.titleClassification of Intrahepatic Cholangiocarcinoma into Perihilar Versus Peripheral Subtypept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1242pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage1232pt_PT
oaire.citation.titleAnnals of Surgical Oncologypt_PT
oaire.citation.volume31pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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