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High-Grade Urothelial Carcinoma in a Kidney Transplant Recipient After JC Virus Nephropathy: the First Evidence of JC Virus As a Potential Oncovirus in Bladder Cancer

2020Journal article Open access
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dc.contributor.authorQuerido, S
dc.contributor.authorFernandes, I
dc.contributor.authorWeigert, A
dc.contributor.authorCasimiro, S
dc.contributor.authorAlbuquerque, C
dc.contributor.authorRamos, S
dc.contributor.authorAdragão, T
dc.contributor.authorLuz, I
dc.contributor.authorPaixão, P
dc.contributor.authorChasqueira, M
dc.contributor.authorSantos, M
dc.contributor.authorMachado, D
dc.date.accessioned2021-08-13T12:18:11Z
dc.date.available2021-08-13T12:18:11Z
dc.date.issued2020
dc.description.abstractKidney transplant (KT) recipients have an increased risk for urothelial carcinoma. A role for JC virus (JCV) in human cancers is not yet proved but there is an increasingly reported association between BK virus (BKV) nephropathy and renourinary neoplasms. We report a KT recipient who developed a high-grade urothelial carcinoma 5 years after a diagnosis of JCV nephropathy and 9 years after kidney transplantation. Neoplastic tissue was positive for JCV DNA by real-time polymerase chain reaction (PCR). Immunochemical staining showed strong positivity for cell cycle markers (p16, p53, and Ki67) and for early viral protein JCV large T antigen (JCV LTag; using a broad polyomavirus antibody); however, late viral protein (VP1) stained negative. In contrast, in non-neoplastic urothelium, JCV DNA and all immunochemical markers were negative. These facts suggest that malignancy was induced by JCV. To the best of our knowledge, this is the first report of urothelial high-grade carcinoma associated with JCV nephropathy in a KT recipient.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAm J Transplant. 2020 Apr;20(4):1188-1191.pt_PT
dc.identifier.doi10.1111/ajt.15663.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/3831
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.subjectCHLC PAT CLINpt_PT
dc.subjectBK Virus / geneticspt_PT
dc.subjectHumanspt_PT
dc.subjectCarcinoma, Transitional Cellpt_PT
dc.subjectDNA, Viral / geneticspt_PT
dc.subjectJC Virus / geneticspt_PT
dc.subjectKidney Transplantation / adverse effectspt_PT
dc.subjectPolyomavirus Infections / complicationspt_PT
dc.subjectRetroviridaept_PT
dc.subjectTumor Virus Infectionspt_PT
dc.subjectUrinary Bladder Neoplasms / etiologypt_PT
dc.titleHigh-Grade Urothelial Carcinoma in a Kidney Transplant Recipient After JC Virus Nephropathy: the First Evidence of JC Virus As a Potential Oncovirus in Bladder Cancerpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1191pt_PT
oaire.citation.startPage1188pt_PT
oaire.citation.titleAmerican Journal of Transplantationpt_PT
oaire.citation.volume20pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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