Publication
Validation of Two US Risk Scores for Percutaneous Coronary Intervention in a Single-Center Portuguese Population of Patients with Acute Coronary Syndrome
| dc.contributor.author | Timóteo, AT | |
| dc.contributor.author | Viveiros Monteiro, A | |
| dc.contributor.author | Portugal, G | |
| dc.contributor.author | Teixeira, P | |
| dc.contributor.author | Aidos, H | |
| dc.contributor.author | Ferreira, ML | |
| dc.contributor.author | Cruz Ferreira, R | |
| dc.date.accessioned | 2016-03-09T12:32:22Z | |
| dc.date.available | 2016-03-09T12:32:22Z | |
| dc.date.issued | 2016-02 | |
| dc.description.abstract | INTRODUCTION: New scores have been developed and validated in the US for in-hospital mortality risk stratification in patients undergoing coronary angioplasty: the National Cardiovascular Data Registry (NCDR) risk score and the Mayo Clinic Risk Score (MCRS). We sought to validate these scores in a European population with acute coronary syndrome (ACS) and to compare their predictive accuracy with that of the GRACE risk score. METHODS: In a single-center ACS registry of patients undergoing coronary angioplasty, we used the area under the receiver operating characteristic curve (AUC), a graphical representation of observed vs. expected mortality, and net reclassification improvement (NRI)/integrated discrimination improvement (IDI) analysis to compare the scores. RESULTS: A total of 2148 consecutive patients were included, mean age 63 years (SD 13), 74% male and 71% with ST-segment elevation ACS. In-hospital mortality was 4.5%. The GRACE score showed the best AUC (0.94, 95% CI 0.91-0.96) compared with NCDR (0.87, 95% CI 0.83-0.91, p=0.0003) and MCRS (0.85, 95% CI 0.81-0.90, p=0.0003). In model calibration analysis, GRACE showed the best predictive power. With GRACE, patients were more often correctly classified than with MCRS (NRI 78.7, 95% CI 59.6-97.7; IDI 0.136, 95% CI 0.073-0.199) or NCDR (NRI 79.2, 95% CI 60.2-98.2; IDI 0.148, 95% CI 0.087-0.209). CONCLUSION: The NCDR and Mayo Clinic risk scores are useful for risk stratification of in-hospital mortality in a European population of patients with ACS undergoing coronary angioplasty. However, the GRACE score is still to be preferred. | pt_PT |
| dc.identifier.citation | Rev Port Cardiol. 2016 Feb;35(2):73-8 | pt_PT |
| dc.identifier.doi | 10.1016/j.repc.2015.09.018 | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.17/2413 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Sociedade Portuguesa de Cardiologia | pt_PT |
| dc.subject | HSM CAR | pt_PT |
| dc.subject | Acute Coronary Syndrome/therapy | pt_PT |
| dc.subject | Europe | pt_PT |
| dc.subject | Hospital Mortality | pt_PT |
| dc.subject | Percutaneous Coronary Intervention/mortality | pt_PT |
| dc.subject | Registries | |
| dc.subject | Risk Assessment | |
| dc.title | Validation of Two US Risk Scores for Percutaneous Coronary Intervention in a Single-Center Portuguese Population of Patients with Acute Coronary Syndrome | pt_PT |
| dc.title.alternative | Validação de Dois Scores de Risco Americanos para a Intervenção Coronária Percutânea num Estudo Unicêntrico da População Portuguesa para Doentes com Síndrome Coronária Aguda | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 78 | pt_PT |
| oaire.citation.startPage | 73 | pt_PT |
| oaire.citation.title | Revista Portuguesa de Cardiologia | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |