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Chronic Urticaria in the Real-Life Clinical Practice Setting in Portugal: Baseline Results from the Non-Interventional Multicentre AWARE Study

2019-02-28Journal article Open access
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dc.contributor.authorCosta, C
dc.contributor.authorRosmaninho, I
dc.contributor.authorGuilherme, A
dc.contributor.authorFerreira, J
dc.contributor.authorAntunes, J
dc.contributor.authorPina, A
dc.contributor.authorPrates, S
dc.contributor.authorGaspar-Marques, J
dc.contributor.authorAzevedo, F
dc.contributor.authorCunha, AP
dc.contributor.authorBrito, C
dc.contributor.authorMassa, A
dc.contributor.authorSousa, JT
dc.contributor.authorVelho, GC
dc.contributor.authorRaposo, I
dc.contributor.authorPinto, GM
dc.contributor.authorSousa, Vi
dc.contributor.authorMartins, AR
dc.date.accessioned2019-04-08T11:46:24Z
dc.date.available2019-04-08T11:46:24Z
dc.date.issued2019-02-28
dc.description.abstractThere is a paucity of information regarding chronic urticaria patients' care in a real-world setting. The objective of this study was to report and evaluate the baseline characteristics of Portuguese chronic urticaria patients refractory to H1-antihistamines included in the AWARE study. MATERIAL AND METHODS: This is a non-interventional cohort study. Adult patients with a diagnosis of chronic urticaria with symptoms for at least two months, refractory to H1-antihistamines, consulting one of the 10 participating urticaria centers throughout Portugal have been included in the study. Baseline sociodemographic data, medical history, clinical parameters, medication, weekly urticaria activity score, and dermatology quality of life index have been collected. RESULTS: Seventy six patients were included, of which 76.3% were women. The majority of patients had a diagnosis of chronic spontaneous urticaria (88.2%) and 39.5% had angioedema. Around 91.0% of patients were medicated with non-sedative H1-antihistamines and 35.4% with a third line therapy. Median dermatology quality of life index was 5.0 and median weekly urticaria activity score was 13.0. DISCUSSION: The baseline results suggest that patients with chronic urticaria refractory to H1-antihistamines are being under-treated in the real-world setting. CONCLUSION: The AWARE study demonstrates the real impact of chronic urticaria on Portuguese patients refractory to H1-antihistamines treatment, and 30% report a very large or extremely large deleterious effect on their quality of life. The follow-up of these patients will allow evaluating strategies aimed at optimizing disease control.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationActa Med Port. 2019;32(2):133-140pt_PT
dc.identifier.doi10.20344/amp.9496pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/3244
dc.language.isoporpt_PT
dc.peerreviewedyespt_PT
dc.publisherCentro Editor Livreiro da Ordem dos Médicospt_PT
dc.subjectChronic Diseasept_PT
dc.subjectChronic Urticaria*pt_PT
dc.subjectCohort Studiespt_PT
dc.subjectOmalizumabpt_PT
dc.subjectQuality of Lifept_PT
dc.subjectPortugalpt_PT
dc.subjectHDE ALERpt_PT
dc.subjectHSAC DERpt_PT
dc.subjectTreatment Outcome
dc.subjectAdult
dc.subjectHumans
dc.titleChronic Urticaria in the Real-Life Clinical Practice Setting in Portugal: Baseline Results from the Non-Interventional Multicentre AWARE Studypt_PT
dc.title.alternativeUrticária Crónica na Prática Clínica de Vida Real em Portugal: Características Basais do Estudo Multicêntrico Não-Intervencional AWAREpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage140pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage133pt_PT
oaire.citation.volume32pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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