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Impact of Cardiorespiratory Fitness on the Obesity Paradox in Heart Failure with Reduced Ejection Fraction

2020Journal article Open access
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dc.contributor.authorIlhão Moreira, R
dc.contributor.authorPereira da Silva, T
dc.contributor.authorValentim Gonçalves, A
dc.contributor.authorFeliciano, J
dc.contributor.authorRio, P
dc.contributor.authorSoares, RM
dc.contributor.authorCruz Ferreira, R
dc.date.accessioned2020-12-15T14:57:05Z
dc.date.available2020-12-15T14:57:05Z
dc.date.issued2020
dc.description.abstractBackground: Higher body mass index (BMI) has been associated with improved outcomes in heart failure with reduced ejection fraction. This finding has led to the concept of the obesity paradox. Objective: To investigate the impact of exercise tolerance and cardiorespiratory capacity on the obesity paradox. Methods: Outpatients with symptomatic heart failure and left ventricular ejection fraction (LVEF) ≤ 40%, followed up in our center, prospectively underwent baseline comprehensive evaluation including clinical, laboratorial, electrocardiographic, echocardiographic, and cardiopulmonary exercise testing parameters. The study population was divided according to BMI (< 25, 25 - 29.9, and ≥ 30 kg/m2). All patients were followed for 60 months. The combined endpoint was defined as cardiac death, urgent heart transplantation, or need for mechanical circulatory support. P value < 0.05 was considered significant. Results: In the 282 enrolled patients (75% male, 54 ± 12 years, BMI 27 ± 4 kg/m2, LVEF 27% ± 7%), the composite endpoint occurred in 24.4% during follow-up. Patients with higher BMI were older, and they had higher LVEF and serum sodium levels, as well as lower ventilatory efficiency (VE/VCO2) slope. VE/VCO2 and peak oxygen consumption (pVO2) were strong predictors of prognosis (p < 0.001). In univariable Cox regression analysis, higher BMI was associated with better outcomes (HR 0.940, CI 0.886 - 0.998, p 0.042). However, after adjusting for either VE/VCO2 slope or pVO2, the protective role of BMI disappeared. Survival benefit of BMI was not evident when patients were grouped according to cardiorespiratory fitness class (VE/VCO2, cut-off value 35, and pVO2, cut-off value 14 mL/kg/min). Conclusion: These results suggest that cardiorespiratory fitness outweighs the relationship between BMI and survival in patients with heart failure.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationArq Bras Cardiol. 2020 Oct;115(4):639-645.pt_PT
dc.identifier.doi10.36660/abc.20190337pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/3532
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSociedade Brasileira de Cardiologiapt_PT
dc.subjectExercise Testpt_PT
dc.subjectFemalept_PT
dc.subjectHumanspt_PT
dc.subjectMalept_PT
dc.subjectObesitypt_PT
dc.subjectOxygen Consumptionpt_PT
dc.subjectPrognosispt_PT
dc.subjectStroke Volumept_PT
dc.subjectVentricular Function, Leftpt_PT
dc.subjectCardiorespiratory Fitnesspt_PT
dc.subjectHeart Failurept_PT
dc.subjectHSM CARpt_PT
dc.titleImpact of Cardiorespiratory Fitness on the Obesity Paradox in Heart Failure with Reduced Ejection Fractionpt_PT
dc.title.alternativeO Impacto da Aptidão Cardiorrespiratória no Paradoxo da Obesidade em Insuficiência Cardíaca com Fração de Ejeção Reduzidapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage645pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage639pt_PT
oaire.citation.titleArquivos Brasileiros de Cardiologiapt_PT
oaire.citation.volume115pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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