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Retinal Oxygen Metabolism in Healthy Subjects and Glaucoma Patients

2014Journal article Open access
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dc.contributor.authorOlafsdottir, O
dc.contributor.authorVandewalle, E
dc.contributor.authorAbegão Pinto, L
dc.contributor.authorGeirsdottir, A
dc.contributor.authorClerck, E
dc.contributor.authorStalmans, P
dc.contributor.authorGottfredsdottir, MS
dc.contributor.authorKristjansdottir, J
dc.contributor.authorCalster, J
dc.contributor.authorZeyen, T
dc.contributor.authorStefánsson, E
dc.contributor.authorStalmans, I
dc.date.accessioned2021-08-11T13:54:24Z
dc.date.available2021-08-11T13:54:24Z
dc.date.issued2014
dc.description.abstractBackground: To test whether retinal oxygen metabolism is different in glaucoma patients compared with healthy subjects. Methods: This was a two-centre study where retinal vessel oxygen saturation was measured in glaucoma patients and healthy individuals with a non-invasive spectrophotometric retinal oximeter. Visual fields were obtained in the glaucoma patients. Results: No statistical difference was found in retinal oxygen saturation in arterioles (p=0.16), venules (p=0.16) and arteriovenous difference (p=0.24) when all glaucoma patients (n=74) were compared with healthy individuals (n=89). When patients with advanced glaucoma (visual field mean defect (MD ≥ 10 dB, n=21)) were compared with healthy individuals, the oxygen saturation in venules was higher in glaucoma patients (58.2% ± 5.4% vs 53.8% ± 6.4%; p=0.0054, mean ± SD) and the arteriovenous difference was lower in glaucoma patients (36.4% ± 4.7% vs 39.5% ± 5.7%; p=0.021). In glaucoma patients with mild glaucoma (visual field MD ≤ 5 dB, n=33), no statistical differences were found in retinal oxygen saturation compared with healthy individuals. Conclusions: Glaucoma patients with advanced glaucoma have higher oxygen saturation in venules and lower arteriovenous difference in oxygen saturation compared with healthy individuals. The decreased arteriovenous difference in severe glaucoma may be related to lower oxygen consumption secondary to neuropathy.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBr J Ophthalmol. 2014 Mar;98(3):329-33.pt_PT
dc.identifier.doi10.1136/bjophthalmol-2013-303162.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/3806
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBMJpt_PT
dc.subjectHSAC OFTpt_PT
dc.subjectBlood Pressure / physiologypt_PT
dc.subjectFemalept_PT
dc.subjectMalept_PT
dc.subjectMiddle Agedpt_PT
dc.subjectDark Adaptationpt_PT
dc.subjectGlaucoma, Open-Angle / physiopathologypt_PT
dc.subjectHumanspt_PT
dc.subjectIntraocular Pressure / physiologypt_PT
dc.subjectLow Tension Glaucoma / physiopathologypt_PT
dc.subjectOximetrypt_PT
dc.subjectOxygen / bloodpt_PT
dc.subjectOxygen Consumption / physiologypt_PT
dc.subjectProspective Studiespt_PT
dc.subjectRetinal Vessels / physiologypt_PT
dc.subjectVisual Field Testspt_PT
dc.subjectVisual Fields / physiologypt_PT
dc.titleRetinal Oxygen Metabolism in Healthy Subjects and Glaucoma Patientspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage333pt_PT
oaire.citation.startPage329pt_PT
oaire.citation.titleBritish Journal of Ophthalmologypt_PT
oaire.citation.volume98pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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