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Relationship of Left Ventricular Global Longitudinal Strain with Cardiac Autonomic Denervation As Assessed by 123I-mIBG Scintigraphy in Patients with Heart Failure with Reduced Ejection Fraction Submitted to Cardiac Resynchronization Therapy: Assessment of Cardiac Autonomic Denervation by GLS in Patients with Heart Failure with Reduced Ejection Fraction Submitted to CRT

2019Journal article Open access
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dc.contributor.authorCoutinho Cruz, M
dc.contributor.authorAbreu, A
dc.contributor.authorPortugal, G
dc.contributor.authorSanta-Clara, H
dc.contributor.authorSilva Cunha, P
dc.contributor.authorOliveira, MM
dc.contributor.authorSantos, V
dc.contributor.authorOliveira, L
dc.contributor.authorRio, P
dc.contributor.authorRodrigues, I
dc.contributor.authorMorais, LA
dc.contributor.authorCruz Ferreira, R
dc.contributor.authorMota Carmo, M
dc.date.accessioned2020-02-06T15:56:53Z
dc.date.available2020-02-06T15:56:53Z
dc.date.issued2019
dc.description.abstractBACKGROUND: Heart failure (HF) is associated with cardiac autonomic denervation (AD), which can be non-invasively assessed by 123I-metaiodobenzylguanidine (123I-mIBG) scintigraphy and has prognostic implications. We aimed to study the relationship between myocardial contractility assessed by global longitudinal strain (GLS) and AD assessed by 123I-mIBG scintigraphy in advanced HF. METHODS/RESULTS: BETTER-HF is a prospective randomized clinical trial including HF patients (pts) submitted to cardiac resynchronization therapy (CRT) who are submitted to a clinical, echocardiographic, and scintigraphic assessment before and 6 months after CRT. 81 pts were included. An echocardiographic response (absolute increase in left ventricular ejection fraction ≥ 10%) was observed in 73.7% of pts. A higher baseline late heart-to-mediastinum ratio (HMR) was associated with a better echocardiographic response. There was a significant association between late HMR and GLS at baseline and 6 months. At baseline, GLS had an AUC of 0.715 for discrimination for a late HMR < 1.6. A GLS cut-off of - 9% maximized the likelihood of correctly classifying a pt as having severe AD (HMR < 1.6). CONCLUSION: Myocardial contractility as assessed by GLS is moderately correlated with AD as assessed by 123I-mIBG scintigraphy and has a good discrimination for the identification of severe cardiac denervation. GLS may allow for a more readily accessible estimation of the degree of AD in advanced HF pts.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Nucl Cardiol. 2019 Jun;26(3):869-879.pt_PT
dc.identifier.doi10.1007/s12350-017-1148-9pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/3422
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Verlagpt_PT
dc.subjectHSM CARpt_PT
dc.subject3-Iodobenzylguanidinept_PT
dc.subjectAdultpt_PT
dc.subjectAgedpt_PT
dc.subjectAged, 80 and overpt_PT
dc.subjectAutonomic Nervous System Diseases / diagnostic imaging
dc.subjectAutonomic Nervous System Diseases / etiology
dc.subjectCardiac Resynchronization Therapy
dc.subjectFemale
dc.subjectMale
dc.subjectHumans
dc.subjectHeart Failure / diagnostic imaging
dc.subjectHeart Failure / physiopathology
dc.subjectHeart Failure / therapy
dc.subjectMiddle Aged
dc.subjectRadionuclide Imaging
dc.subjectRadiopharmaceuticals
dc.subjectStroke Volume / physiology
dc.subjectVentricular Function, Left / physiology
dc.titleRelationship of Left Ventricular Global Longitudinal Strain with Cardiac Autonomic Denervation As Assessed by 123I-mIBG Scintigraphy in Patients with Heart Failure with Reduced Ejection Fraction Submitted to Cardiac Resynchronization Therapy: Assessment of Cardiac Autonomic Denervation by GLS in Patients with Heart Failure with Reduced Ejection Fraction Submitted to CRTpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage879pt_PT
oaire.citation.issue3pt_PT
oaire.citation.startPage869pt_PT
oaire.citation.titleJournal of Nuclear Cardiologypt_PT
oaire.citation.volume26pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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