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Prognostic Value of MicroRNA-203a Expression in Breast Cancer

2016-09Journal article Open access
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dc.contributor.authorCosta Gomes, B
dc.contributor.authorMartins, M
dc.contributor.authorLopes, P
dc.contributor.authorMorujão, I
dc.contributor.authorOliveira, M
dc.contributor.authorAraújo, A
dc.contributor.authorRueff, J
dc.contributor.authorRodrigues, AS
dc.date.accessioned2018-11-29T16:06:34Z
dc.date.available2018-11-29T16:06:34Z
dc.date.issued2016-09
dc.description.abstractTumor heterogeneity and the poor outcome of breast cancer (BC) patients have led researchers to define new markers of this disease. In recent years, microRNA expression patterns have proven to be valuable disease indicators. The level of miR-203a, in particular, was shown to be altered in different types of cancer. The objective of the present study was to assess the relationship between miR-203a expression and clinicopathological features of BC in a Portuguese cohort. The expression levels of miR‑203a were analyzed in 109 formalin‑fixed paraffin-embedded paired normal and tumor tissue samples. Significant overexpression of miR‑203a in the tumor tissues was found (1.7-fold higher) compared to the expression in the normal adjacent tissues (p=0.003). In addition, several clinicopathological characteristics presented an association with higher miR-203a expression levels. Tumors with diameter ≤18.5 mm (1.5-fold; p=0.019), tumors positive for estrogen receptor (fold-change, 1.71; p=0.042), progesterone receptor (fold-change, 1.50; p=0.046) and negative for HER2 (fold-change, 1.50; p=0.016) and high Ki-67 index (fold-change, 2.60; p=0.024) presented a significant difference in miR-203a expression compared with adjacent normal tissues. Tumors without invasion of lymph nodes also presented higher expression of miR-203a (fold-change, 2.40; p=0.004). With regard to histological classification, ductal carcinomas in situ (fold-change, 2.20; p=0.028) and invasive carcinoma NOS (fold-change, 1.71; p=0.009) displayed significantly higher expression of miR-203a. Moreover, we found a significant downregulation of miR-203a with increased stage in invasive lobular carcinomas, suggesting that miR-203a could represent a potential marker to discriminate stages in invasive lobular carcinomas.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationOncol Rep. 2016 Sep;36(3):1748-56.pt_PT
dc.identifier.doi10.3892/or.2016.4913pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/3115
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpandidos Publicationspt_PT
dc.subjectAdultpt_PT
dc.subjectAgedpt_PT
dc.subjectAged, 80 and overpt_PT
dc.subjectBreast Neoplasmspt_PT
dc.subjectFemalept_PT
dc.subjectGene Expression Regulation, Neoplasticpt_PT
dc.subjectHumanspt_PT
dc.subjectMicroRNAspt_PT
dc.subjectMiddle Agedpt_PT
dc.subjectPolymerase Chain Reactionpt_PT
dc.subjectPortugalpt_PT
dc.subjectPrognosispt_PT
dc.subjectTranscriptomept_PT
dc.subjectCHLC PAT CLINpt_PT
dc.subjectCHLC CIRpt_PT
dc.titlePrognostic Value of MicroRNA-203a Expression in Breast Cancerpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1756pt_PT
oaire.citation.issue3pt_PT
oaire.citation.startPage1748pt_PT
oaire.citation.titleOncology Reportspt_PT
oaire.citation.volume36pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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