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Cerebrospinal Fluid Cytokines in Multiple System Atrophy: a Cross-Sectional Catalan MSA Registry Study

2019Journal article Open access
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dc.contributor.authorCompta, Y
dc.contributor.authorDias, S
dc.contributor.authorGiraldo, D
dc.contributor.authorPérez-Soriano, A
dc.contributor.authorMuñoz, E
dc.contributor.authorSaura, J
dc.contributor.authorFernández, M
dc.contributor.authorBravo, P
dc.contributor.authorCámara, A
dc.contributor.authorPulido-Salgado, M
dc.contributor.authorPainous, C
dc.contributor.authorRíos, J
dc.contributor.authorMartí, MJ
dc.date.accessioned2021-04-30T15:57:58Z
dc.date.available2021-04-30T15:57:58Z
dc.date.issued2019
dc.description.abstractIntroduction: Neuroinflammation is a potential player in neurodegenerative conditions, particularly the aggressive ones, such as multiple system atrophy (MSA). Previous reports on cytokine levels in MSA using serum or cerebrospinal fluid (CSF) have been inconsistent, including small samples and a limited number of cytokines, often without comparison to Parkinson's disease (PD), a main MSA differential diagnosis. Methods: Cross-sectional study of CSF levels of 38 cytokines using a multiplex assay in 73 participants: 39 MSA patients (19 with parkinsonian type [MSAp], 20 with cerebellar type [MSAc]; 31 probable, 8 possible), 19 PD patients and 15 neurologically unimpaired controls. None of the participants was under non-steroidal anti-inflammatory drugs at the time of the lumbar puncture. Results: There were not significant differences in sex and age among participants. In global non-parametric comparisons FDR-corrected for multiple comparisons, CSF levels of 5 cytokines (FGF-2, IL-10, MCP-3, IL-12p40, MDC) differed among the three groups. In pair-wise FDR-corrected non-parametric comparisons 12 cytokines (FGF-2, eotaxin, fractalkine, IFN-α2, IL-10, MCP-3, IL-12p40, MDC, IL-17, IL-7, MIP-1β, TNF-α) were significantly higher in MSA vs. non-MSA cases (PD + controls pooled together). Of these, MCP-3 and MDC were the most significant ones, also differed in MSA vs. PD, and were significant MSA-predictors in binary logistic regression models and ROC curves adjusted for age. CSF levels of fractalkine and MIP-1α showed a strong and significant positive correlation with UMSARS-2 scores. Conclusion: Increased CSF levels of cytokines such as MCP-3, MDC, fractalkine and MIP-1α deserve consideration as potential diagnostic or severity biomarkers of MSA.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationParkinsonism Relat Disord. 2019 Aug;65:3-12.pt_PT
dc.identifier.doi10.1016/j.parkreldis.2019.05.040pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/3684
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.subjectAgedpt_PT
dc.subjectBiomarkerspt_PT
dc.subjectCross-Sectional Studiespt_PT
dc.subjectCytokinespt_PT
dc.subjectFemalept_PT
dc.subjectHumanspt_PT
dc.subjectMalept_PT
dc.subjectMiddle Agedpt_PT
dc.subjectMultiple System Atrophypt_PT
dc.subjectPilot Projectspt_PT
dc.subjectSpainpt_PT
dc.subjectRegistriespt_PT
dc.subjectCHLC NEUpt_PT
dc.titleCerebrospinal Fluid Cytokines in Multiple System Atrophy: a Cross-Sectional Catalan MSA Registry Studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage12pt_PT
oaire.citation.startPage3pt_PT
oaire.citation.titleParkinsonism & Related Disorderspt_PT
oaire.citation.volume65pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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