Repository logo
 
Publication

A Comprehensive Preoperative Predictive Score for Post-Hepatectomy Liver Failure After Hepatocellular Carcinoma Resection Based on Patient Comorbidities, Tumor Burden, and Liver Function: the CTF Score.

2022-12Text Open access
Simple item page
dc.contributor.authorAlaimo, Laura
dc.contributor.authorEndo, Yutaka
dc.contributor.authorLima, Henrique A
dc.contributor.authorMoazzam, Zorays
dc.contributor.authorShaikh, Chanza Fahim
dc.contributor.authorRuzzenente, Andrea
dc.contributor.authorGuglielmi, Alfredo
dc.contributor.authorRatti, Francesca
dc.contributor.authorAldrighetti, Luca
dc.contributor.authorPinto Marques, Hugo
dc.contributor.authorCauchy, François
dc.contributor.authorLam, Vincent
dc.contributor.authorPoultsides, George A
dc.contributor.authorPopescu, Irinel
dc.contributor.authorAlexandrescu, Sorin
dc.contributor.authorMartel, Guillaume
dc.contributor.authorHugh, Tom
dc.contributor.authorEndo, Itaru
dc.contributor.authorPawlik, Timothy M
dc.date.accessioned2025-08-05T15:48:45Z
dc.date.available2025-08-05T15:48:45Z
dc.date.issued2022-12
dc.description.abstractBackground: Post-hepatectomy liver failure (PHLF) is a dreaded complication following liver resection for hepatocellular carcinoma (HCC) with a high mortality rate. We sought to develop a score based on preoperative factors to predict PHLF. Methods: Patients who underwent resection for HCC between 2000 and 2020 were identified from an international multi-institutional database. Factors associated with PHLF were identified and used to develop a preoperative comorbidity-tumor burden-liver function (CTF) predictive score. Results: Among 1785 patients, 106 (5.9%) experienced PHLF. On multivariate analysis, several factors were associated with PHLF including high Charlson comorbidity index (CCI ≥ 5) (OR 2.80, 95%CI, 1.08-7.26), albumin-bilirubin (ALBI) (OR 1.99, 95%CI, 1.10-3.56), and tumor burden score (TBS) (OR 1.06, 95%CI, 1.02-1.11) (all p < 0.05). Using the beta-coefficients of these variables, a weighted predictive score was developed and made available online ( https://alaimolaura.shinyapps.io/PHLFriskCalculator/ ). The CTF score (c-index = 0.67) performed better than Child-Pugh score (CPS) (c-index = 0.53) or Barcelona clinic liver cancer system (BCLC) (c-index = 0.57) to predict PHLF. A high CTF score was also an independent adverse prognostic factor for survival (HR 1.61, 95%CI, 1.12-2.30) and recurrence (HR 1.36, 95%CI, 1.08-1.71) (both p = 0.01). Conclusion: Roughly 1 in 20 patients experienced PHLF following resection of HCC. Patient (i.e., CCI), tumor (i.e., TBS), and liver function (i.e., ALBI) factors were associated with risk of PHLF. These preoperative factors were incorporated into a novel CTF tool that was made available online, which outperformed other previously proposed tools.eng
dc.identifier.citationJ Gastrointest Surg . 2022 Dec;26(12):2486-2495. doi: 10.1007/s11605-022-05451-5.
dc.identifier.doiJ Gastrointest Surg . 2022;26(12):2486-2495. doi: 10.1007/s11605-022-05451-5.
dc.identifier.pmid36100827
dc.identifier.urihttp://hdl.handle.net/10400.17/5134
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSpringer
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectHCC CIR
dc.subjectHumans
dc.subjectPrognosis
dc.subjectBilirubin
dc.subjectCarcinoma
dc.subjectHepatocellular* / pathology
dc.subjectComorbidity
dc.subjectHepatectomy / adverse effects
dc.subjectLiver Failure* / epidemiology
dc.subjectLiver Failure* / etiology
dc.subjectLiver Neoplasms* / pathology
dc.subjectRetrospective Studies
dc.subjectSerum Albumin
dc.titleA Comprehensive Preoperative Predictive Score for Post-Hepatectomy Liver Failure After Hepatocellular Carcinoma Resection Based on Patient Comorbidities, Tumor Burden, and Liver Function: the CTF Score.eng
dc.typetext
dspace.entity.typePublication
oaire.citation.endPage2495
oaire.citation.issue12
oaire.citation.startPage2486
oaire.citation.titleJournal of Gastrointestinal Surgery
oaire.citation.volume26
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
JGSurg.pdf
Size:
1.79 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
4.03 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

CIR - Artigos