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Factors Associated With Asthma Control in 121 Preschool Children

2021Journal article Open access
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dc.contributor.authorLeiria-Pinto, P
dc.contributor.authorCarreiro-Martins, P
dc.contributor.authorPeralta, I
dc.contributor.authorMarques, J
dc.contributor.authorFinelli, E
dc.contributor.authorAlves, C
dc.contributor.authorBelo, J
dc.contributor.authorAlves, M
dc.contributor.authorPapoila, AL
dc.contributor.authorNeuparth, N
dc.date.accessioned2023-04-13T14:11:01Z
dc.date.available2023-04-13T14:11:01Z
dc.date.issued2021
dc.description.abstractBackground and objectives: Data on risk factors for uncontrolled asthma in preschool children are controversial. Objective: This study aims to explore the association between clinical and functional parameters and the lack of asthma control in preschool children. Methods: Children aged 3-5 years with asthma and healthy controls were recruited. A questionnaire was used to identify potential risk factors for uncontrolled asthma, as defined by the Global INitiative for Asthma criteria. Lung function and bronchial reversibility were evaluated through impulse oscillometry and spirometry. Adjusted odds ratios were estimated based on multivariable generalized additive regression models. The discriminative ability of the models was measured by the area under the receiver operating characteristic curve (AUC). Results: The study population comprised 121 children (107 with asthma and 14 healthy controls). Fifty-three patients (50%) had uncontrolled asthma. After adjustment, the variables associated with an increased risk of lack of control were as follows: "More than 3 flare-ups in the last 12 months", "Moderate to severe rhinitis", and "Relative variation in postbronchodilator FVC and FEV1". The AUC of the final models that included variation in FVC or FEV1 were 0.82 and 0.81, respectively. The R5-20, R5-20%, and AX z-score values of the healthy group were lower than those of children with asthma. Conclusion: In preschool children, clinical and functional parameters are associated with uncontrolled asthma. More studies are needed to confirm the usefulness of impulse oscillometry.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Investig Allergol Clin Immunol . 2021 Dec 21;31(6):471-480pt_PT
dc.identifier.doi10.18176/jiaci.0630pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/4490
dc.language.isospapt_PT
dc.peerreviewedyespt_PT
dc.publisherEsmon Publicidadpt_PT
dc.subjectAsthma* / diagnosispt_PT
dc.subjectAsthma* / epidemiologypt_PT
dc.subjectChild, Preschoolpt_PT
dc.subjectForced Expiratory Volumept_PT
dc.subjectOdds Ratiopt_PT
dc.subjectOscillometrypt_PT
dc.subjectRespiratory Function Testspt_PT
dc.subjectSpirometrypt_PT
dc.subjectHDE ALERpt_PT
dc.subjectHDE CINVpt_PT
dc.titleFactors Associated With Asthma Control in 121 Preschool Childrenpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage480pt_PT
oaire.citation.issue6pt_PT
oaire.citation.startPage471pt_PT
oaire.citation.titleJournal of Investigational Allergy and Clinical Immunologypt_PT
oaire.citation.volume31pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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