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Nailfold Capillaroscopy and Autoimmune Connective Tissue Diseases in Patients From a Portuguese Nailfold Capillaroscopy Clinic

2020-02Journal article Open access
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dc.contributor.authorBernardino, V
dc.contributor.authorRodrigues, A
dc.contributor.authorLladó, A
dc.contributor.authorPanarra, A
dc.date.accessioned2021-06-23T14:01:31Z
dc.date.available2021-06-23T14:01:31Z
dc.date.issued2020-02
dc.description.abstractRaynaud's phenomenon (RP) is frequent in autoimmune connective tissue diseases (AICTD) and its approach includes nailfold capillaroscopy (NFC), as it is a non-invasive technique that permits direct visualization of the microcirculation. The aim of this study is to analyze and establish clinical correlations between NFC findings and particular aspects of autoimmune disorders. This is a retrospective study. Clinical data from patients attending our NFC clinic were reviewed. Inclusion criteria included AICTD previous diagnosis, which included systemic sclerosis (SSc), mixed connective tissue disease (MCTD), systemic lupus erythematosus (SLE), Sjögren syndrome, inflammatory idiopathic myopathies (IIM), rheumatoid arthritis, undifferentiated connective tissue disease and antiphospholipid syndrome (APS). Videocap® version 3.0 biomicroscope was used. NFC score was determined. For statistics, SPSS software was utilized. 384 patients were included; most of them were women, with mean age of 47 years. RP was present in 91% of the patients, with greater prevalence in SSc and MCTD. Scleroderma pattern was the most prevalent NFC pattern, mainly in SSc, MCTD and IIM. Mean capillary density was reduced in IIM, SSc and MCTD. NFC score was worse in SSc, IIM and MCTD. In patients with AICTD, RP is related to microvascular damage and worse NFC score. NFC scleroderma pattern correlates with SSc classification criteria score. In MCTD, scleroderma pattern relates to myositis. SLE and APS reveal significant hemorrhages, but not related to APS antibodies. This study highlights the possible role of NFC as biomarker of AICTD, particularly in SSc and IIM.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRheumatol Int. 2020 Feb;40(2):295-301.pt_PT
dc.identifier.doi10.1007/s00296-019-04427-0pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/3738
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.subjectAdultpt_PT
dc.subjectAgedpt_PT
dc.subjectAntiphospholipid Syndromept_PT
dc.subjectArthritis, Rheumatoidpt_PT
dc.subjectAutoimmune Diseasespt_PT
dc.subjectConnective Tissue Diseasespt_PT
dc.subjectFemalept_PT
dc.subjectHumanspt_PT
dc.subjectLupus Erythematosus, Systemicpt_PT
dc.subjectMalept_PT
dc.subjectMiddle Agedpt_PT
dc.subjectMixed Connective Tissue Diseasept_PT
dc.subjectMyositispt_PT
dc.subjectPortugalpt_PT
dc.subjectRaynaud Diseasept_PT
dc.subjectRetrospective Studiespt_PT
dc.subjectScleroderma, Systemicpt_PT
dc.subjectSjogren's Syndromept_PT
dc.subjectUndifferentiated Connective Tissue Diseasespt_PT
dc.subjectYoung Adultpt_PT
dc.subjectMicroscopic Angioscopypt_PT
dc.subjectHCC MEDpt_PT
dc.titleNailfold Capillaroscopy and Autoimmune Connective Tissue Diseases in Patients From a Portuguese Nailfold Capillaroscopy Clinicpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage301pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage295pt_PT
oaire.citation.titleRheumatology Internationalpt_PT
oaire.citation.volume40pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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