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Distinguishing Kingella kingae from Pyogenic Acute Septic Arthritis in Young Portuguese Children

dc.contributor.authorGouveia, C
dc.contributor.authorSubtil, A
dc.contributor.authorNorte, S
dc.contributor.authorArcangelo, J
dc.contributor.authorSantos, MA
dc.contributor.authorCorte-Real, R
dc.contributor.authorSimões, MJ
dc.contributor.authorCanhão, H
dc.contributor.authorTavares, D
dc.date.accessioned2022-08-17T14:55:26Z
dc.date.available2022-08-17T14:55:26Z
dc.date.issued2022
dc.description.abstractBackground: We aim to identify clinical and laboratorial parameters to distinguish Kingella kingae from pyogenic septic arthritis (SA). (2) Methods: A longitudinal, observational, single-centre study of children < 5 years old with microbiological positive SA admitted to a paediatric hospital from 2013-2020 was performed. Clinical and laboratorial data at admission and at 48 h, as well as on treatment and evolution, were obtained. (3) Results: We found a total of 75 children, 44 with K. kingae and 31 with pyogenic infections (mostly MSSA, S. pneumoniae and S. pyogenes). K. kingae affected younger children with low or absent fever, low inflammatory markers and a favourable prognosis. In the univariate analyses, fever, septic look, CRP and ESR at admission and CRP at 48 h were significantly lower in K. kingae SA. In the multivariate analyses, age > 6 months ≤ 2 years, apyrexy and CRP ≤ 100 mg/L were significative, with an overall predictive positive value of 86.5%, and 88.4% for K. kingae. For this model, ROC curves were capable of differentiating (AUC 0.861, 95% CI 0.767-0.955) K. kingae SA from typical pathogens. (4) Conclusions: Age > 6 months ≤ 2 years, apyrexy and PCR ≤ 100 mg/L were the main predictive factors to distinguish K. kingae from pyogenic SA < 5 years. These data need to be validated in a larger study.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMicroorganisms . 2022 Jun 16;10(6):1233pt_PT
dc.identifier.doi10.3390/microorganisms10061233pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/4214
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)pt_PT
dc.subjectKingella kingaept_PT
dc.subjectSeptic arthritis/acutept_PT
dc.subjectPyogenic infectionspt_PT
dc.subjectHDE INF PEDpt_PT
dc.subjectHDE ORT PEDpt_PT
dc.titleDistinguishing Kingella kingae from Pyogenic Acute Septic Arthritis in Young Portuguese Childrenpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue6pt_PT
oaire.citation.startPage1233pt_PT
oaire.citation.titleMicroorganismspt_PT
oaire.citation.volume10pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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