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Total Luminal Volume Predicts Risk after Endovascular Aneurysm Repair

2020-06Journal article Open access
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dc.contributor.authorOliveira-Pinto, J
dc.contributor.authorSoares Ferreira, R
dc.contributor.authorOliveira, N
dc.contributor.authorHoeks, S
dc.contributor.authorVan Rijn, MJ
dc.contributor.authorRaa, ST
dc.contributor.authorMansilha, A
dc.contributor.authorVerhagen, HJ
dc.contributor.authorBastos Gonçalves, F
dc.date.accessioned2020-10-20T15:37:21Z
dc.date.available2020-10-20T15:37:21Z
dc.date.issued2020-06
dc.description.abstractObjective: Large aneurysm diameter represents a well known predictor of late complications after endovascular aneurysm repair (EVAR). However, the role of the thrombus free lumen inside the abdominal aortic aneurysm (AAA) sac is not clear. It was hypothesised that greater luminal volume represents a relevant risk factor for late complications after EVAR. Methods: A retrospective cohort analysis was performed including all patients undergoing EVAR from 2005 to 2016 at a tertiary referral institution. Pre-operative AAA lumen volume was measured in centre lumen line reconstructions and patients were stratified into quartiles according to luminal volume. The primary endpoint was freedom from AAA related complications. Secondary endpoints were freedom from neck events (type 1A endoleak, migration >5 mm or any pre-emptive neck related intervention), iliac related events (type 1B endoleak or pre-emptive iliac related intervention), and overall survival. Results: Four hundred and four patients were included: 101 in the first quartile (Q1; <61 cm3). Patients with higher luminal volumes had wider, shorter, and more angulated proximal necks. There were more ruptured AAAs, more aorto-uni-iliac implanted devices and patients outside neck instructions for use in the 4th quartile. Five year freedom from AAA related complications was 79%, 66%, 58% and 56%, respectively (p = .007). At five years, freedom from neck related events was 86%, 84%, 73%, and 71%, respectively, for the four groups (p = .009), and freedom from iliac related events was 96%, 91%, 88%, and 88%, respectively (p = .335). On multivariable analysis, luminal volume was an independent predictor of late complications (Q4 vs. Q1 - hazard ratio: 1.91, 95% confidence interval 1.01-3.6, p = .046). Overall survival at five years was not affected by lumen volume (p = .75). Conclusion: AAA luminal volume represents an important risk factor for AAA related complications. This information may be considered when deciding tailoring surveillance protocols after EVAR. However, larger studies are needed to validate this hypothesis.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEur J Vasc Endovasc Surg. 2020 Jun;59(6):918-927.pt_PT
dc.identifier.doi10.1016/j.ejvs.2020.02.011pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/3510
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.subjectAgedpt_PT
dc.subjectAged, 80 and overpt_PT
dc.subjectAorta, Abdominalpt_PT
dc.subjectAortic Aneurysm, Abdominalpt_PT
dc.subjectAortographypt_PT
dc.subjectComputed Tomography Angiographypt_PT
dc.subjectEndovascular Procedurespt_PT
dc.subjectFemalept_PT
dc.subjectFollow-Up Studiespt_PT
dc.subjectHospital Mortalitypt_PT
dc.subjectHumanspt_PT
dc.subjectMalept_PT
dc.subjectMiddle Agedpt_PT
dc.subjectPostoperative Complicationspt_PT
dc.subjectPreoperative Periodpt_PT
dc.subjectProspective Studiespt_PT
dc.subjectRetrospective Studiespt_PT
dc.subjectRisk Assessmentpt_PT
dc.subjectRisk Factorspt_PT
dc.subjectTreatment Outcomept_PT
dc.subjectHSM CIR VASCpt_PT
dc.titleTotal Luminal Volume Predicts Risk after Endovascular Aneurysm Repairpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage927pt_PT
oaire.citation.issue6pt_PT
oaire.citation.startPage918pt_PT
oaire.citation.titleEuropean Journal of Vascular and Endovascular Surgerypt_PT
oaire.citation.volume59pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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