Publication
Does Intake of Bread Supplemented with Wheat Germ Have a Preventive Role on Cardiovascular Disease Risk Markers in Healthy Volunteers? A Randomised, Controlled, Crossover Trial
| dc.contributor.author | Moreira-Rosário, A | |
| dc.contributor.author | Pinheiro, H | |
| dc.contributor.author | Marques, C | |
| dc.contributor.author | Teixeira, JA | |
| dc.contributor.author | Calhau, C | |
| dc.contributor.author | Azevedo, LF | |
| dc.date.accessioned | 2019-11-21T16:49:28Z | |
| dc.date.available | 2019-11-21T16:49:28Z | |
| dc.date.issued | 2019 | |
| dc.description.abstract | OBJECTIVE: Intake of whole grains is associated with a reduced risk of cardiovascular disease (CVD). This evidence is also strong for bran alone, but findings about germ are conflicting. Our aim was to elucidate the role of germ in primary prevention of cardiovascular events, and therefore, a staple food was selected for 6 g of germ supplementation. This corresponds to sixfold increase in the global mean consumption of germ, while preserving the sensory proprieties of refined bread which is crucial for consumer's acceptance. DESIGN: Randomised, double-blinded, crossover, controlled clinical trial with 15-week follow-up comprising a 2-week run-in, two intervention periods of 4 weeks each and a 5-week washout period. SETTING: A single centre in the north of Portugal. PARTICIPANTS: 55 eligible healthy adults (mean age of 34 years and body mass index between 19 and 38 kg/m2) were randomly assigned. INTERVENTIONS: The study consisted of two intervention periods including daily intake of refined wheat bread enriched with 6 g of wheat germ and control (non-enriched bread). OUTCOMES: Changes in fasting cholesterol and triglycerides, fasting and postprandial glucose, insulin sensitivity and C reactive protein. RESULTS: We observed no significant effect of daily intake of wheat germ on cholesterol and triglycerides levels, on postprandial glucose response and on insulin sensitivity. Incremental area under curve glucose and homeostasis model assessment for insulin resistance did not change, suggesting that 6 g of wheat germ have no effect on glucose metabolism. No effect was also observed in the subgroup of participants who complied with the protocol (n=47). CONCLUSIONS: The absence of alterations on lipid and glucose profiles suggests that germ up to 6 g/day may have no preventive effect on CVD risk. However, it is important to investigate other food vehicles that can accommodate higher doses of wheat germ in future studies. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | BMJ Open. 2019 Jan 17;9(1):e023662. | pt_PT |
| dc.identifier.doi | 10.1136/bmjopen-2018-023662 | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.17/3362 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | BMJ Publishing Group | pt_PT |
| dc.subject | HCC INF | pt_PT |
| dc.subject | Biomarkers/blood | pt_PT |
| dc.subject | Blood Glucose/metabolism | pt_PT |
| dc.subject | Bread | pt_PT |
| dc.subject | Cardiovascular Diseases/prevention & control | pt_PT |
| dc.subject | Cholesterol/blood | |
| dc.subject | Cross-Over Studies | |
| dc.subject | Double-Blind Method | |
| dc.subject | Recommended Dietary Allowances | |
| dc.subject | Triglycerides/blood | |
| dc.subject | Triticum | |
| dc.subject | Whole Grains | |
| dc.title | Does Intake of Bread Supplemented with Wheat Germ Have a Preventive Role on Cardiovascular Disease Risk Markers in Healthy Volunteers? A Randomised, Controlled, Crossover Trial | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.issue | 1 | pt_PT |
| oaire.citation.startPage | e023662 | pt_PT |
| oaire.citation.title | BMJ Open | pt_PT |
| oaire.citation.volume | 9 | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |