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Apolipoprotein E Polymorphism Interacts with Cigarette Smoking in Progression of Multiple Sclerosis

2009-07Journal article Open access
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dc.contributor.authorSena, A
dc.contributor.authorCouderc, R
dc.contributor.authorFerret-Sena, V
dc.contributor.authorPedrosa, R
dc.contributor.authorAndrade, ML
dc.contributor.authorAraujo, C
dc.contributor.authorRoque, R
dc.contributor.authorCascais, MJ
dc.contributor.authorMorais, MG
dc.date.accessioned2017-04-19T12:44:14Z
dc.date.available2017-04-19T12:44:14Z
dc.date.issued2009-07
dc.description.abstractBACKGROUND AND PURPOSE: The influence of apolipoprotein E (ApoE) polymorphism on clinical severity of multiple sclerosis (MS) is still controversial. Cigarette smoking has been suggested to influence the progression of disability in these patients. In this study, we aimed to investigate whether an interaction of smoking with the ApoE polymorphism influences the progression of disability in MS patients. METHODS: Smoking history from 205 female patients with MS was obtained. Clinical data collected include age at onset, disease duration, annual relapse rate, the Expanded Disability Status Scale (EDSS) and the Multiple Sclerosis Severity Score (MSSS). ApoE polymorphism was examined in all patients and stratified according to smoking status and associations with the clinical data investigated. RESULTS: There were no significant associations between cigarette smoking and any of the clinical characteristics in the whole group of patients. In women carrying the ApoE E4 isoform, smokers had a lower EDSS (P = 0.033) and MSSS (P = 0.023) in comparison with non-smokers. CONCLUSION: Our data suggest that in women with MS carrying the ApoE E4 isoform, cigarette smoking may have a protective influence on disease progression and accumulation of disability. These findings need to be confirmed by future large longitudinal studies.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEur J Neurol. 2009 Jul;16(7):832-7pt_PT
dc.identifier.doi10.1111/j.1468-1331.2009.02603.xpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/2674
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.subjectAdultpt_PT
dc.subjectApolipoproteins Ept_PT
dc.subjectDisability Evaluationpt_PT
dc.subjectDisease Progressionpt_PT
dc.subjectFemalept_PT
dc.subjectHumanspt_PT
dc.subjectMiddle Agedpt_PT
dc.subjectMultiple Sclerosispt_PT
dc.subjectPolymorphism, Geneticpt_PT
dc.subjectSeverity of Illness Indexpt_PT
dc.subjectSmokingpt_PT
dc.subjectGenetic Predisposition to Diseasept_PT
dc.subjectCHLC NEUpt_PT
dc.titleApolipoprotein E Polymorphism Interacts with Cigarette Smoking in Progression of Multiple Sclerosispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage837pt_PT
oaire.citation.issue7pt_PT
oaire.citation.startPage832pt_PT
oaire.citation.titleEuropean Journal of Neurologypt_PT
oaire.citation.volume16pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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