Publication
Long-Term Survival (>25 Years) of Deceased Donor Kidney Transplant Recipients: a Single-Center Experience
| dc.contributor.author | Rego, F | |
| dc.contributor.author | Alçântara, P | |
| dc.contributor.author | Buinho, F | |
| dc.contributor.author | Gomes da Costa, A | |
| dc.contributor.author | Rodrigues Pena, J | |
| dc.date.accessioned | 2016-01-20T16:56:38Z | |
| dc.date.available | 2016-01-20T16:56:38Z | |
| dc.date.issued | 2015-05 | |
| dc.description.abstract | INTRODUCTION: The aim of this preliminary work is to analyze the clinical features of 52 patients with a functional transplanted kidney for >25 years (all first transplant and all deceased donor recipients) and to compare with a similar though more complete study from Hôpital Necker-Paris 2012. METHODS: The mean graft survival at 25 years is 12.7% and at 30 years is 10%. The actual mean serum creatinine concentration is 1.3 mg/L. We analyzed recipient age (mean, 35.9 years) and gender (29 men and 23 women). Donor age was 26.7 ± 10.3 years. Seven patients (13.4%) were transplanted with 1 HLA mismatch, 42.3% with 2 mismatches, and 44.2% with 3 mismatches. Mean cold ischemia time was 15.45 ± 7.7 hours. Of the recipients, 76% had immediate graft function; 38% experienced 1 acute rejection episode and 4 patients had 2 rejection crises. The initial immunosuppressive regimen was azathioprine (AZA) + prednisolone (Pred) in 14 patients, cyclosporin (CSA) + Pred in 13 patients, and CSA + AZA + Pred in 25 patients. Of these patients, 19% maintained their initial regimen, and 54% (28 patients) were very stable on a mixed CSA regimen for >25 years. RESULTS: We present the major complications (diabetes, neoplasia, and hepatitis C virus positivity). CONCLUSION: Our results in deceased donor kidney recipients for >25 years are similar to the mixed population (deceased donors and living donors) presented by the Necker group, although 54% of our patients remain on CSA immunosuppression, contradicting the idea that its use is not compatible with good long-term kidney function in transplant recipients. | pt_PT |
| dc.identifier.citation | Transplant Proc. 2015 May;47(4):967-70 | pt_PT |
| dc.identifier.doi | 10.1016/j.transproceed.2015.03.027 | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.17/2368 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Elsevier | pt_PT |
| dc.subject | HCC CIR | pt_PT |
| dc.subject | Forecasting | pt_PT |
| dc.subject | Adult | pt_PT |
| dc.subject | Aged | pt_PT |
| dc.subject | Graft Rejection/mortality | pt_PT |
| dc.subject | Graft Survival | pt_PT |
| dc.subject | Kidney Transplantation/mortality | pt_PT |
| dc.subject | Living Donors | pt_PT |
| dc.subject | Paris/epidemiology | pt_PT |
| dc.subject | Retrospective Studies | pt_PT |
| dc.subject | Survival Rate/trends | pt_PT |
| dc.subject | Transplant Recipients | pt_PT |
| dc.title | Long-Term Survival (>25 Years) of Deceased Donor Kidney Transplant Recipients: a Single-Center Experience | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 970 | pt_PT |
| oaire.citation.startPage | 967 | pt_PT |
| oaire.citation.title | Transplantation Proceedings | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |