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A Post Hoc Analysis on Rhythm and High Intensity Interval Training in Cardiac Resynchronization Therapy

2019-08Journal article Open access
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dc.contributor.authorMelo, X
dc.contributor.authorAbreu, A
dc.contributor.authorSantos, V
dc.contributor.authorSilva Cunha, P
dc.contributor.authorOliveira, MM
dc.contributor.authorPinto, R
dc.contributor.authorMota Carmo, M
dc.contributor.authorFernhall, B
dc.contributor.authorSanta-Clara, H
dc.date.accessioned2020-02-07T16:22:14Z
dc.date.available2020-02-07T16:22:14Z
dc.date.issued2019-08
dc.description.abstractObjectives. Evaluate the effects of a 6-month High Intensity Interval Training (HIIT) program on (1) functional capacity and health-related quality of life, (2) multiple blood biomarkers, (3) echocardiographic parameters, and (4) exercise performance, in patients in cardiac resynchronization therapy (CRT) stratified by the presence of atrial fibrillation (AF), targeting the following questions: (1) Does CRT provide similar benefits in patients in AF and sinus rhythm (SR)?; and (2) Does HIIT provides similar benefits in patients in AF and SR? Design. Estimates were available at baseline and 6 months after CRT implantation in 37 patients with heart failure. Patients were randomized after CRT to a 24-week HIIT group or to a usual care group (CON). In this sub-analysis, HIIT (AF = 7; SR = 11) and CON (AF = 9; SR = 10) were stratified by the presence of AF. Results. Patients in AF benefitted to a lesser degree from CRT in functional status than patients in SR (23.8-46.0%). However, HIIT induced superior improvements in patients in AF compared to CON (23.9-61.0%). Decreases in TNF-α (8.5-42.9%), BNP (15.3-34.6%) and left ventricular mass (9.6-26.2%) were only observed in patients in SR, whereas increases in peak oxygen uptake were only observed in patients in AF (19.5-23.2%). HIIT improved exercise capacity (8.8-59.4%) in patients in SR. Conclusions. Patients in AF or SR undergoing CRT demonstrated distinct benefits from device implantation and from HIIT as an adjunctive therapeutic strategy. This suggests that both mainstay and adjunctive therapeutics may need to be managed differently in patients in AF and SR.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationScand Cardiovasc J. 2019 Aug;53(4):197-205.pt_PT
dc.identifier.doi10.1080/14017431.2019.1630747pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/3438
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherTaylor & Francispt_PT
dc.subjectAgedpt_PT
dc.subjectAtrial Fibrillationpt_PT
dc.subjectBiomarkerspt_PT
dc.subjectCardiac Rehabilitationpt_PT
dc.subjectFemalept_PT
dc.subjectHeart Failurept_PT
dc.subjectHumanspt_PT
dc.subjectMalept_PT
dc.subjectMiddle Agedpt_PT
dc.subjectRecovery of Functionpt_PT
dc.subjectTime Factorspt_PT
dc.subjectTreatment Outcomept_PT
dc.subjectCardiac Resynchronization Therapypt_PT
dc.subjectExercise Tolerancept_PT
dc.subjectHeart Ratept_PT
dc.subjectHigh-Intensity Interval Trainingpt_PT
dc.subjectHSM CARpt_PT
dc.titleA Post Hoc Analysis on Rhythm and High Intensity Interval Training in Cardiac Resynchronization Therapypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage205pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage197pt_PT
oaire.citation.titleScandinavian Cardiovascular Journalpt_PT
oaire.citation.volume53pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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