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Dakin's Solution in the Treatment of Severe Diabetic Foot Infections

2020Journal article Open access
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dc.contributor.authorDuarte, B
dc.contributor.authorFormiga, A
dc.contributor.authorNeves, J
dc.date.accessioned2022-04-22T14:34:38Z
dc.date.available2022-04-22T14:34:38Z
dc.date.issued2020
dc.description.abstractAcute necrotising diabetic foot (DF) infections are common, costly, and do not infrequently result in debilitating major lower-extremity amputations. Dakin's solution is a long-standing topical antiseptic that has shown benefit in this clinical setting, but its use is undermined by a presumed risk of cytotoxicity. In this single-centre case series, we retrospectively evaluated 24 patients with severe necrotising DF infections treated with a cyclical instillation of Dakin's solution at a referral multidisciplinary DF unit. Most patients achieved favourable outcomes in infection control and limb salvage, with only one patient (4.2%) requiring a major (at or above-the-ankle) amputation. The mean time to complete or near-complete wound granulation was 5.4 weeks. Of the 12 patients who completed 12 or more months of longitudinal follow up, only 2 (12.2%) had a wound recurrence. In this severe DF infection patient cohort, Dakin's solution led to a clinically meaningful improvement. No remarkable impairment in the wound-healing process was observed.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationInt Wound J. 2020 Apr;17(2):277-284.pt_PT
dc.identifier.doi10.1111/iwj.13268.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/4045
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.subjectHSAC DERpt_PT
dc.subjectHCC CIRpt_PT
dc.subjectAdultpt_PT
dc.subjectAgedpt_PT
dc.subjectAdministration, Topicalpt_PT
dc.subjectFemalept_PT
dc.subjectAged, 80 and overpt_PT
dc.subjectMiddle Agedpt_PT
dc.subjectMalept_PT
dc.subjectDiabetic Foot / complications*pt_PT
dc.subjectDiabetic Foot / drug therapypt_PT
dc.subjectDisinfectants / therapeutic usept_PT
dc.subjectHumanspt_PT
dc.subjectFollow-Up Studiespt_PT
dc.subjectLimb Salvage / methods*pt_PT
dc.subjectRetrospective Studiespt_PT
dc.subjectSeverity of Illness Indexpt_PT
dc.subjectSodium Hypochlorite / therapeutic use*pt_PT
dc.subjectTreatment Outcomept_PT
dc.subjectWound Healing / drug effects*pt_PT
dc.subjectWound Infection / diagnosispt_PT
dc.subjectWound Infection / drug therapy*pt_PT
dc.subjectWound Infection / etiologypt_PT
dc.titleDakin's Solution in the Treatment of Severe Diabetic Foot Infectionspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage284pt_PT
oaire.citation.startPage277pt_PT
oaire.citation.titleInternational Wound Journalpt_PT
oaire.citation.volume17pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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