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Prescribing of Non-Steroidal Anti-Inflammatory Drugs to Patients with Diabetes Mellitus in Portugal

2019-02-28Journal article Open access
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dc.contributor.authorBigotte Vieira, M
dc.contributor.authorNeves, JS
dc.contributor.authorBaptista, RB
dc.contributor.authorLeitão, L
dc.contributor.authorViegas Dias, C
dc.contributor.authorVicente, R
dc.contributor.authorNascimento, N
dc.contributor.authorLeite, CC
dc.contributor.authorRocha, I
dc.contributor.authorMagriço, R
dc.date.accessioned2019-04-08T11:39:43Z
dc.date.available2019-04-08T11:39:43Z
dc.date.issued2019-02-28
dc.description.abstractINTRODUCTION: Portugal presents the highest incidence of stage 5 chronic kidney disease in Europe. It is speculated that a high consumption of non-steroidal anti-inflammatory drugs (NSAIDS) may contribute to this high incidence. Our aim was to characterize the prescription of non-steroidal anti-inflammatory drugs to patients with diabetes mellitus in Portugal. MATERIAL AND METHODS: We analyzed the national prescription database in triennium 2015 - 2017. In patients with diabetes mellitus, we evaluated the prescription of non-steroidal anti-inflammatory drugs according to age, gender and region of the patient and specialty of the prescribing physician. We evaluated the prescription of non-steroidal anti-inflammatory drugs in all patients with diabetes mellitus, in patients with presumed renal impairment, and in those with concomitant prescription of angiotensin converting enzyme inhibitors or angiotensin receptor antagonists. RESULTS: We analyzed 23 320 620 prescriptions, corresponding to 610 157 adults, including 104 306 patients with diabetes mellitus. The most prescribed non-steroidal anti-inflammatory drugs were ibuprofen (20.1%), metamizole (14.7%), and diclofenac (11.4%). The prescription of non-steroidal anti-inflammatory drugs was higher in females, in patients aged 51 - 70 years and in the Alentejo region. Non-steroidal anti-inflammatory drugs were prescribed to 70.6% of patients with diabetes mellitus, from which 10.6% were prescribed ≥ 10 packages during the three years. Among patients with diabetes mellitus on angiotensin converting enzyme inhibitors/angiotensin receptor antagonists and with presumed reduction in kidney function, 69.3% were prescribed non-steroidal anti-inflammatory drugs and 11.5% were prescribed ≥ 10 packages during the three years. DISCUSSION: The level of prescribing of non-steroidal anti-inflammatory drugs to patients with diabetes mellitus is high. The concern of reducing non-steroidal anti-inflammatory drugs prescription to patients already on angiotensin converting enzyme inhibitors/angiotensin receptor antagonists and/or decreased renal function does not seem to exist. CONCLUSION: In Portugal, the level of prescribing of non-steroidal anti-inflammatory drugs to patients with diabetes mellitus should be reduced, particularly in the subgroups identified with higher prescription and with higher risk of progression to stage 5 chronic kidney disease.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationActa Med Port. 2019; 32(2):119-125.pt_PT
dc.identifier.doi10.20344/amp.10815pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/3243
dc.language.isoporpt_PT
dc.peerreviewedyespt_PT
dc.publisherCentro Editor Livreiro da Ordem dos Médicospt_PT
dc.subjectAngiotensin Receptor Antagonistspt_PT
dc.subjectAngiotensin-Converting Enzyme Inhibitorspt_PT
dc.subjectAnti-Inflammatory Agentspt_PT
dc.subjectNon-Steroidalpt_PT
dc.subjectDiabetes Mellituspt_PT
dc.subjectRenal Insufficiency, Chronicpt_PT
dc.subjectHDE PEDpt_PT
dc.subjectHCC NEFpt_PT
dc.titlePrescribing of Non-Steroidal Anti-Inflammatory Drugs to Patients with Diabetes Mellitus in Portugalpt_PT
dc.title.alternativePrescrição de Anti-Inflamatórios Não Esteroides a Doentes com Diabetes Mellitus em Portugalpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage125pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage119pt_PT
oaire.citation.volume32pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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