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BRAF V600E Mutation and 9p21: CDKN2A/B and MTAP Co-Deletions - Markers in the Clinical Stratification of Pediatric Gliomas

2018-12-17Journal article Open access
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dc.contributor.authorFrazão, L
dc.contributor.authorMartins, MC
dc.contributor.authorNunes, VM
dc.contributor.authorPimentel, J
dc.contributor.authorFaria, C
dc.contributor.authorMiguéns, J
dc.contributor.authorSagarribay, A
dc.contributor.authorMatos, M
dc.contributor.authorSalgado, D
dc.contributor.authorNunes, S
dc.contributor.authorMafra, M
dc.contributor.authorRoque, L
dc.date.accessioned2019-04-08T11:08:47Z
dc.date.available2019-04-08T11:08:47Z
dc.date.issued2018-12-17
dc.description.abstractGenetic alterations in pediatric primary brain tumors can be used as diagnostic and prognostic markers and are the basis for the development of new target therapies that, ideally, would be associated with lower mortality and morbidity. This study evaluates the incidence and interplay of the presence of BRAF V600E mutation and chromosomal 9p21 deletions in a series of 100 pediatric gliomas, aiming to determine the role of these alterations in recurrence and malignant transformation, and to verify if they could be used in the clinical set for stratifying patients for tailored therapies and surveillance.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBMC Cancer. 2018 Dec 17;18(1):1259pt_PT
dc.identifier.doi10.1186/s12885-018-5120-0pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/3239
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBMCpt_PT
dc.subjectAdolescentpt_PT
dc.subjectBrain Neoplasmspt_PT
dc.subjectChildpt_PT
dc.subjectChild, Preschoolpt_PT
dc.subjectChromosomes, Human, Pair 9pt_PT
dc.subjectCohort Studiespt_PT
dc.subjectCyclin-Dependent Kinase Inhibitor p15pt_PT
dc.subjectCyclin-Dependent Kinase Inhibitor p16pt_PT
dc.subjectFemalept_PT
dc.subjectGene Deletionpt_PT
dc.subjectGliomapt_PT
dc.subjectHumanspt_PT
dc.subjectIn Situ Hybridization, Fluorescencept_PT
dc.subjectInfantpt_PT
dc.subjectMalept_PT
dc.subjectPhosphorylasespt_PT
dc.subjectProto-Oncogene Proteins B-rafpt_PT
dc.subjectSequence Analysis, DNApt_PT
dc.subjectMutationpt_PT
dc.subjectHDE NCIRpt_PT
dc.titleBRAF V600E Mutation and 9p21: CDKN2A/B and MTAP Co-Deletions - Markers in the Clinical Stratification of Pediatric Gliomaspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue1pt_PT
oaire.citation.startPage1259pt_PT
oaire.citation.volume18pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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